The major objective of the SNRP proposal is to establish an Alaskan Basic Neuroscience Program (ABNP) at the University of Alaska to expand, facilitate and stimulate neuroscience research related to the dramatically increasing health problems of the Alaskan Native population. A second objective is to facilitate the development of collaborative research with scientists at other institutions that can contribute to this effort. A third objective is to stimulate the active participation of Alaskan Native students in the projects of the proposed Program resulting in more Alaskan Native neuroscience students. The ABNP will carry out interdisciplinary research to study mechanisms of neuroprotective adaptations. This will be accomplished by four specific aims: 1) develop an administrative core directly under the Provost that will provide the most effective environment to develop our neuroscientists, 2) develop a research program around the theme of neuroprotective adaptations and increase collaborations with neuroscientists on this theme, 3) develop an emphasis on neuroscience graduate education, and 4) upgrade an existing tissue culture/imaging facility to state-of-the-art standards. An External Advisory Committee composed of experts in the field of neuroscience research will monitor the program. An Internal Advisory Committee will meet to discuss results, future research directions and advice the Program Director on all matters related to the functioning of the ABNP. Neuro protective adaptations in response to stress summarizes the focus of the proposed research. Research will address this theme through a number of hypotheses and interrelated questions focusing on neuroprotective adaptations associated with neuroprotective mechanisms during hibernation and signal transduction in the control of cell death, neuronal regeneration, circadian rhythms and thermoregulation. The results generated by the effort at UAC and the collaborators will be greater than the sum of the individual efforts because of the program's efforts because of the program's impact on the development of a culture of health related research at UAF.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54NS041069-01
Application #
6285790
Study Section
Special Emphasis Panel (ZNS1-SRB-L (02))
Program Officer
Dowling, Gayathri
Project Start
2000-09-30
Project End
2005-08-31
Budget Start
2000-09-30
Budget End
2001-08-31
Support Year
1
Fiscal Year
2000
Total Cost
$1,546,820
Indirect Cost
Name
University of Alaska Fairbanks
Department
Type
Organized Research Units
DUNS #
615245164
City
Fairbanks
State
AK
Country
United States
Zip Code
99775
Bhowmick, Saurav; Moore, Jeanette T; Kirschner, Daniel L et al. (2017) Acidotoxicity via ASIC1a Mediates Cell Death during Oxygen Glucose Deprivation and Abolishes Excitotoxicity. ACS Chem Neurosci 8:1204-1212
Bhowmick, Saurav; Moore, Jeanette T; Kirschner, Daniel L et al. (2017) Arctic ground squirrel hippocampus tolerates oxygen glucose deprivation independent of hibernation season even when not hibernating and after ATP depletion, acidosis, and glutamate efflux. J Neurochem 142:160-170
Bhowmick, Saurav; Drew, Kelly L (2017) Arctic ground squirrel resist peroxynitrite-mediated cell death in response to oxygen glucose deprivation. Free Radic Biol Med 113:203-211
Zhan, Qiong; Buchanan, Gordon F; Motelow, Joshua E et al. (2016) Impaired Serotonergic Brainstem Function during and after Seizures. J Neurosci 36:2711-22
Drew, Kelly L; Wells, Matthew; McGee, Rebecca et al. (2016) Arctic ground squirrel neuronal progenitor cells resist oxygen and glucose deprivation-induced death. World J Biol Chem 7:168-77
Hoffman, M; Taylor, B E; Harris, M B (2016) Evolution of lung breathing from a lungless primitive vertebrate. Respir Physiol Neurobiol 224:11-6
Vayndorf, Elena M; Scerbak, Courtney; Hunter, Skyler et al. (2016) Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis. NPJ Aging Mech Dis 2:
Richerson, George B; Boison, Detlev; Faingold, Carl L et al. (2016) From unwitnessed fatality to witnessed rescue: Pharmacologic intervention in sudden unexpected death in epilepsy. Epilepsia 57 Suppl 1:35-45
Ebbesson, Sven O E; Voruganti, Venkata S; Higgins, Paul B et al. (2015) Fatty acids linked to cardiovascular mortality are associated with risk factors. Int J Circumpolar Health 74:28055
Schnurr, Theresia M; Reynolds, Arleigh J; Duffy, Lawrence K et al. (2015) Glucose transporter-4 in white blood cells of young and old sled dogs: a model for human biomarker development. Polar Rec (Gr Brit) 51:160-164

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