The long-range goal of this application is to augment and strength the neuroscience research capabilities of faculty and trainees at Meharry Medical College. Moreover, neuroscience faculty members at Meharry Medical College seek to assist in improving the competitive status of the school's research relative to other health science centers in the United States. The Specialized Neuroscience Research Program (SNRP) will help to create a research environment wherein faculty and trainees will enhance their research skills and capabilities to efficiently conduct high quality research, to disseminate their research findings through peer- reviewed publications and presentations at national meetings, and to compete with greater success for independent extramural research funds.
The specific aims (measurable objectives) of the current applications are to: 1) facilitate the acquisition of mainstream funding by each of the subproject PIs by the end of the project period; 2) attain a 100% level of extramural funding by Neuroscience Center faculty and promote the acquisition of an additional three mainstream extramural awards by the end of the project period; and 3) increase the number of peer-reviewed publications by neuroscience investigators to a mean of two per year by the end of the project period. The Meharry SNRP is a joint effort involving Vanderbilt University and the University of Alabama at Birmingham. The proposed program consists of a core and two collaborative research subprojects. The core provides administrative support for neuroscience faculty with an emphasis on the collaborative projects. Core faculty development activities include grantwriters' workshops, technical workshops, a seminar program and an annual regional neuroscience symposium.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
1U54NS041071-01
Application #
6286138
Study Section
Special Emphasis Panel (ZNS1-SRB-L (02))
Program Officer
Jett, David A
Project Start
2000-09-30
Project End
2005-08-31
Budget Start
2000-09-30
Budget End
2001-08-31
Support Year
1
Fiscal Year
2000
Total Cost
$1,053,769
Indirect Cost
Name
Meharry Medical College
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37208
Charlton, Clivel G (2014) Methylation reactions at dopaminergic nerve endings, serving as biological off-switches in managing dopaminergic functions. Neural Regen Res 9:1110-1
Dhanushkodi, Nisha R; Mohankumar, Vidyarani; Raju, Ramaswamy (2012) Sindbis virus induced phosphorylation of IRF3 in human embryonic kidney cells is not dependent on mTOR. Innate Immun 18:325-32
Li, Zhu; Chadalapaka, Gayathri; Ramesh, Aramandla et al. (2012) PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Toxicol Sci 125:233-47
Jules, G E; Pratap, S; Ramesh, A et al. (2012) In utero exposure to benzo(a)pyrene predisposes offspring to cardiovascular dysfunction in later-life. Toxicology 295:56-67
King, Jennifer M; Muthian, Gladson; Mackey, Veronica et al. (2011) L-Dihydroxyphenylalanine modulates the steady-state expression of mouse striatal tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine and its metabolites in an MPTP mouse model of Parkinson's disease. Life Sci 89:638-43
Kawai, Yumiko; Garduño, Lakisha; Theodore, Melanie et al. (2011) Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem 286:7629-40
Dhanushkodi, Nisha R; Mohankumar, Vidyarani; Pokkali, Supriya et al. (2011) Lipopolysaccharide inhibits Sindbis virus-induced IP-10 release in human peripheral blood mononuclear cells. Viral Immunol 24:237-43
Halder, Sunil K; Goodwin, J Shawn; Al-Hendy, Ayman (2011) 1,25-Dihydroxyvitamin D3 reduces TGF-beta3-induced fibrosis-related gene expression in human uterine leiomyoma cells. J Clin Endocrinol Metab 96:E754-62
Mittal, Mukul K; Singh, Kshipra; Misra, Smita et al. (2011) SLUG-induced elevation of D1 cyclin in breast cancer cells through the inhibition of its ubiquitination. J Biol Chem 286:469-79
Ansah, Twum A; Ferguson, Marcus C; Nayyar, Tultul (2011) The 5-HT(2A) Receptor Antagonist M100907 Produces Antiparkinsonian Effects and Decreases Striatal Glutamate. Front Syst Neurosci 5:48

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