Abstract

This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The major goal of this project is to study the potential use of vitamin D in tissue fibrosis degeneration. The hypothesis will be tested through the following specific aims:
Aim 1. To determine whether vitamin D promotes an anti-fibrotic phenotype in multipotent mesenchymal cells.
Aim 2. To study whether vitamin D inhibits cell proliferation and promotes cell cycle arrest in multipotent C3H-10T (1/2)) cells without inducing apoptosis.
Aim 3. To determine the role of vitamin D on the in vitro differentiation of a mouse mesenchymal pluripotent stem cell line (C3H-10T (1/2)) into alternative cell lineages.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54RR019234-05S1
Application #
7724765
Study Section
Special Emphasis Panel (ZRR1-RCMI-2 (01))
Project Start
2007-08-01
Project End
2009-07-31
Budget Start
2007-08-01
Budget End
2009-07-31
Support Year
5
Fiscal Year
2008
Total Cost
$250,426
Indirect Cost

  Institution

Name
Charles R. Drew University of Medicine & Science
Department
Type
Schools of Medicine
DUNS #
785877408
City
Los Angeles
State
CA
Country
United States
Zip Code
90059

  Publications

Artaza, Jorge N; Contreras, Sandra; Garcia, Leah A et al. (2011) Vitamin D and cardiovascular disease: potential role in health disparities. J Health Care Poor Underserved 22:23-38
Sinha-Hikim, Indrani; Shen, Ruoqing; Kovacheva, Ekaterina et al. (2010) Inhibition of apoptotic signalling in spermine-treated vascular smooth muscle cells by a novel glutathione precursor. Cell Biol Int 34:503-11
Releford, Bill J; Frencher Jr, Stanley K; Yancey, Antronette K (2010) Health promotion in barbershops: balancing outreach and research in African American communities. Ethn Dis 20:185-8
Kim, Hyun Ju; Yuan, Jun; Norris, Keith et al. (2010) High-calorie diet partially ameliorates dysregulation of intrarenal lipid metabolism in remnant kidney. J Nutr Biochem 21:999-1007
Rettig, Richard; Vargas, Roberto; Norris, Keith et al. (2010) A 'quiet revolution' in nephrology. Nephrol News Issues 24:18-9, 23
Calderón, José Luis; Bazargan, Mohsen; Sangasubana, Nisaratana et al. (2010) A comparison of two educational methods on immigrant Latinas breast cancer knowledge and screening behaviors. J Health Care Poor Underserved 21:76-90
Jones, Loretta; Lu, Michael C; Lucas-Wright, Aziza et al. (2010) One Hundred Intentional Acts of Kindness toward a Pregnant Woman: building reproductive social capital in Los Angeles. Ethn Dis 20:S2-36-40
Releford, Bill J; Frencher Jr, Stanley K; Yancey, Antronette K et al. (2010) Cardiovascular disease control through barbershops: design of a nationwide outreach program. J Natl Med Assoc 102:336-45
Artaza, Jorge N; Sirad, Fara; Ferrini, Monica G et al. (2010) 1,25(OH)2vitamin D3 inhibits cell proliferation by promoting cell cycle arrest without inducing apoptosis and modifies cell morphology of mesenchymal multipotent cells. J Steroid Biochem Mol Biol 119:73-83
Jones, Loretta; Collins, Barry E (2010) Participation in action: the Healthy African American Families community conference model. Ethn Dis 20:S2-15-20

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