This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Driving Biological Project 5: Proteolytic Pathways in Acute Vascular Response .Maintenance of vascular network is crucial to all mammals. We will test the hypothesis thatprotease-dependent post-translational pathways regulate the maintenance (homeostasis) of vascularnetworks. The major components of the vasular network are endothelial cells, vascular smoothmuscle cells (VSMCs or mural cells) and extracellular matrix (ECM) molecules. Underhomeostatic conditions, networks are maintained in a quiescent state; however, following physiologic orpathologic stimulation, innate programs are rapidly inactivated/activated fostering vascular remodeling.One consequence of these events is vasodilation, and subsequent leakage of plasma proteins intointerstitium. We plan to investigate the proteolytic pathways involved in this acute vascular response
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