Abstract

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1. Primary objective of this study is to establish testosterone dose-response relationships in surgically menopausal women with low testosterone concentrations for a range of androgen-dependent outcomes, including sexual function, fat-free mass, thigh muscle strength and leg power, several domains of neurocognitive function, plasma lipids, apolipoproteins and lipoprotein particles, and insulin sensitivity. 2. The secondary objective is to determine the range of testosterone doses and subsequent plasma testosterone concentrations that are associated with improvements in sexual, physical and neurocognitive functions and that can be safely administered to women without significant adverse effects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54RR026138-02
Application #
8173594
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2010-07-01
Project End
2011-06-30
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
2
Fiscal Year
2010
Total Cost
$41,822
Indirect Cost

  Institution

Name
Charles R. Drew University of Medicine & Science
Department
Type
Other Domestic Higher Education
DUNS #
785877408
City
Los Angeles
State
CA
Country
United States
Zip Code
90059

  Publications

Hanuscin, Chris; Zahmatkesh, Golara; Shirazi, Anaheed et al. (2018) Socio-Demographic and Mental Health Profile of Admitted Cases of Self-Inflicted Harm in the US Population. Int J Environ Res Public Health 15:
Kermah, Dulcie; Shaheen, Magda; Pan, Deyu et al. (2017) Association between secondhand smoke and obesity and glucose abnormalities: data from the National Health and Nutrition Examination Survey (NHANES 1999-2010). BMJ Open Diabetes Res Care 5:e000324
Paz, Sylvia H; Jones, Loretta; Calderón, José L et al. (2017) Readability and Comprehension of the Geriatric Depression Scale and PROMIS® Physical Function Items in Older African Americans and Latinos. Patient 10:117-131
Berman, Barbara A; Jones, Loretta; Jones, Felica et al. (2017) How can we help African American substance users stop smoking? client and agency perspectives. J Ethn Subst Abuse :1-17
Badr El-Din, Nariman K; Abdel Fattah, Salma M; Pan, Deyu et al. (2016) Chemopreventive Activity of MGN-3/Biobran Against Chemical Induction of Glandular Stomach Carcinogenesis in Rats and Its Apoptotic Effect in Gastric Cancer Cells. Integr Cancer Ther 15:NP26-NP34
Ghoneum, Mamdooh; Felo, Nouran (2015) Selective induction of apoptosis in human gastric cancer cells by Lactobacillus kefiri (PFT), a novel kefir product. Oncol Rep 34:1659-66
Ogunyemi, Omolola; Kermah, Dulcie (2015) Machine Learning Approaches for Detecting Diabetic Retinopathy from Clinical and Public Health Records. AMIA Annu Symp Proc 2015:983-90
Ghoneum, Mamdooh H; Badr El-Din, Nariman K; Abdel Fattah, Salma M et al. (2015) Hydroferrate fluid, MRN-100, provides protection against chemical-induced gastric and esophageal cancer in Wistar rats. Int J Biol Sci 11:295-303
Sinha-Hikim, I; Duran, P; Shen, R et al. (2015) Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Horm Metab Res 47:280-3
Kahn, Richard; Davidson, Mayer B (2014) The reality of type 2 diabetes prevention. Diabetes Care 37:943-9

Showing the most recent 10 out of 99 publications