Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory Grants--Cooperative Agreements (U56)
Project #
1U56CA112963-01
Application #
6990439
Study Section
Special Emphasis Panel (ZCA1-GRB-V (O1))
Project Start
2004-09-30
Project End
2007-08-31
Budget Start
2004-09-30
Budget End
2005-08-31
Support Year
1
Fiscal Year
2004
Total Cost
$290,193
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Chan, Jason; Kinsella, Michael T; Willis, Joseph E et al. (2013) A Predictive Genetic Signature for Response to Fluoropyrimidine-Based Neoadjuvant Chemoradiation in Clinical Stage II and III Rectal Cancer. Front Oncol 3:288
Gurkan-Cavusoglu, Evren; Avadhani, Sriya; Liu, Lili et al. (2013) Developing an in silico model of the modulation of base excision repair using methoxyamine for more targeted cancer therapeutics. IET Syst Biol 7:27-37
Gurkan-Cavusoglu, Evren; Schupp, Jane E; Kinsella, Timothy J et al. (2013) Quantitative analysis of the effects of iododeoxyuridine and ionising radiation treatment on the cell cycle dynamics of DNA mismatch repair deficient human colorectal cancer cells. IET Syst Biol 7:114-24
Kinsella, Timothy J; Gurkan-Cavusoglu, Evren; Du, Weinan et al. (2011) Integration of Principles of Systems Biology and Radiation Biology: Toward Development of in silico Models to Optimize IUdR-Mediated Radiosensitization of DNA Mismatch Repair Deficient (Damage Tolerant) Human Cancers. Front Oncol 1:20
Gurkan-Cavusoglu, Evren; Schupp, Jane E; Kinsella, Timothy J et al. (2011) Analysis of cell cycle dynamics using probabilistic cell cycle models. Conf Proc IEEE Eng Med Biol Soc 2011:141-4
Zeng, Xuehuo; Kinsella, Timothy J (2010) BNIP3 is essential for mediating 6-thioguanine- and 5-fluorouracil-induced autophagy following DNA mismatch repair processing. Cell Res 20:665-75
Kunos, Charles A; Radivoyevitch, Tomas; Pink, John et al. (2010) Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers. Radiat Res 174:574-81
Kinsella, Timothy J (2009) Coordination of DNA mismatch repair and base excision repair processing of chemotherapy and radiation damage for targeting resistant cancers. Clin Cancer Res 15:1853-9
Seo, Yuji; Kinsella, Timothy J (2009) Essential role of DNA base excision repair on survival in an acidic tumor microenvironment. Cancer Res 69:7285-93
Yan, Tao; Seo, Yuji; Kinsella, Timothy J (2009) Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells. Clin Cancer Res 15:6912-20

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