The long-term goal of this application is to establish at Howard University, an historically African American institution, a strong molecular genetics research program. The program envisioned will greatly enhance research at the Howard University College of Medicine in the area of genetic hemoglobin disorders. The program will focus on basic research needed for a greater understanding of the hemoglobinopathies at the molecular genetics level and for the eventual design of DNA-based treatment strategies. Examples of research areas and capabilities desirable for the program are: regulation of gene expression, site-directed mutagenesis, gene transfer, and gene conversion via oligonucleotide technology. The planned research program will complement basic and clinical studies already on-going at the Howard University Center for Sickle Cell Disease. The program will also benefit other College of Medicine units currently engaged in molecular research related to cardio-vascular and lung disorders. During the first one and one-half year phase of this application, an Advisory Committee will be formed. It will consist primarily of investigators from institutions already conducting research on the molecular biology of hemoglobin. In collaboration with an NHLBI staff member, who will be also a Committee member, this group will help identify and recruit an accomplished research scientist with demonstrated leadership in the molecular genetics areas listed above. The committee will also provide advice to the recruited scientist in the development of a six-year research plan. During the second six-year phase, the recruited scientist will implement the program as principal investigator. After support from this grant ends, the recruited scientist will continue as molecular genetics program director and will qualify for a leadership research position at the College of Medicine.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
HBCU Research Scientist Award (UH1)
Project #
5UH1HL003679-04
Application #
6388404
Study Section
Special Emphasis Panel (ZHL1-CSR-A (S1))
Program Officer
Fakunding, John
Project Start
1996-09-30
Project End
2005-04-30
Budget Start
2001-05-01
Budget End
2002-06-30
Support Year
4
Fiscal Year
2001
Total Cost
$627,998
Indirect Cost
Name
Howard University
Department
Type
Schools of Medicine
DUNS #
056282296
City
Washington
State
DC
Country
United States
Zip Code
20059
Kwagyan, John; Retta, Tamrat M; Ketete, Muluemebet et al. (2015) Obesity and Cardiovascular Diseases in a High-Risk Population: Evidence-Based Approach to CHD Risk Reduction. Ethn Dis 25:208-13
Zhang, Xu; Zhang, Wei; Ma, Shwu-Fan et al. (2014) Iron deficiency modifies gene expression variation induced by augmented hypoxia sensing. Blood Cells Mol Dis 52:35-45
Saraf, Santosh L; Molokie, Robert E; Nouraie, Mehdi et al. (2014) Differences in the clinical and genotypic presentation of sickle cell disease around the world. Paediatr Respir Rev 15:4-12
Walcourt, Asikiya; Kurantsin-Mills, Joseph; Kwagyan, John et al. (2013) Anti-plasmodial activity of aroylhydrazone and thiosemicarbazone iron chelators: effect on erythrocyte membrane integrity, parasite development and the intracellular labile iron pool. J Inorg Biochem 129:43-51
McClain, Donald A; Abuelgasim, Khadega A; Nouraie, Mehdi et al. (2013) Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism. J Mol Med (Berl) 91:59-67
Nekhai, Sergei; Kumari, Namita; Dhawan, Subhash (2013) Role of cellular iron and oxygen in the regulation of HIV-1 infection. Future Virol 8:301-311
Murray, Joseph A; McLachlan, Stela; Adams, Paul C et al. (2013) Association between celiac disease and iron deficiency in Caucasians, but not non-Caucasians. Clin Gastroenterol Hepatol 11:808-14
Paul, Rabindra; Minniti, Caterina P; Nouraie, Mehdi et al. (2013) Clinical correlates of acute pulmonary events in children and adolescents with sickle cell disease. Eur J Haematol 91:62-8
Gordeuk, Victor R; Lovato, Laura; Barton, James et al. (2012) Dietary iron intake and serum ferritin concentration in 213 patients homozygous for the HFEC282Y hemochromatosis mutation. Can J Gastroenterol 26:345-9
Nouraie, Mehdi; Nekhai, Sergei; Gordeuk, Victor R (2012) Sickle cell disease is associated with decreased HIV but higher HBV and HCV comorbidities in U.S. hospital discharge records: a cross-sectional study. Sex Transm Infect 88:528-33

Showing the most recent 10 out of 85 publications