Abstract

During the past year, our research has included studies of: (1) Etiological mechanisms underlying individual differences in alcohol consumption including the effects of age, alcohol exposure, setting, sex, and paternal genetic contributions; (2) The effect of early experience on the development of the nervous system and on the acquisition of social competence and aggressive behaviors; (3) The relationship between serotonin (SHT) and aggression in laboratory and free-ranging rhesus macaques. To obtain a subject pool of aggressive rhesus macaques, we continued to investigate free-ranging adolescent males drawn from a subject pool of 4500 free-ranging rhesus macaques; (4) Developmental patterns of rhesus macaques selectively bred for extremes in CSF 5-HIAA. A major part of the past year has involved the continued investigation of the infants (now in their late childhood) that were selectively bred for extremes in CSF 5-HIAA concentration. Both parents and the infants have been carefully assessed to investigate parental genetic contributions to excessive aggression and alcohol consumption; (5) Continued use of the PET scan paradigm developed over the past two years to assess neurobiological differences in aggression in intact subjects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000277-06
Application #
3745238
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Lorenz, Joseph G; Long, Jeffrey C; Linnoila, Markku et al. (2006) Genetic and other contributions to alcohol intake in rhesus macaques (Macaca mulatta). Alcohol Clin Exp Res 30:389-98
Shannon, Courtney; Schwandt, Melanie L; Champoux, Maribeth et al. (2005) Maternal absence and stability of individual differences in CSF 5-HIAA concentrations in rhesus monkey infants. Am J Psychiatry 162:1658-64
Maestripieri, Dario; Lindell, Stephen G; Ayala, Alejandro et al. (2005) Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior. Neurosci Biobehav Rev 29:51-7
Kumar, Rakesh; Perez-Casanova, Antonio E; Tirado, Grissell et al. (2005) Increased viral replication in simian immunodeficiency virus/simian-HIV-infected macaques with self-administering model of chronic alcohol consumption. J Acquir Immune Defic Syndr 39:386-90
Angeloni, Stephen V; Glynn, Nicole; Ambrosini, Grazia et al. (2004) Characterization of the rhesus monkey ghrelin gene and factors influencing ghrelin gene expression and fasting plasma levels. Endocrinology 145:2197-205
Ayala, Alejandro R; Pushkas, Judy; Higley, J Dee et al. (2004) Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotropin-releasing hormone receptor antagonist in a primate stress paradigm. J Clin Endocrinol Metab 89:5729-37
Gustavsson, Gunnar; Traskman-Bendz, Lil; Higley, J Dee et al. (2003) CSF testosterone in 43 male suicide attempters. Eur Neuropsychopharmacol 13:105-9
Bastian, Meredith L; Sponberg, Anne C; Sponberg, Anne C et al. (2003) Long-term effects of infant rearing condition on the acquisition of dominance rank in juvenile and adult rhesus macaques (Macaca mulatta). Dev Psychobiol 42:44-51
Heinz, A; Jones, D W; Gorey, J G et al. (2003) Serotonin transporter availability correlates with alcohol intake in non-human primates. Mol Psychiatry 8:231-4
Anderson, George M; Bennett, Allyson J; Weld, Katherine P et al. (2002) Serotonin in cisternal cerebrospinal fluid of rhesus monkeys: basal levels and effects of sertraline administration. Psychopharmacology (Berl) 161:95-9

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