Nonhuman Primate Models of Alcohol Consumption and Excessive Aggression

Higley, J D.

Abstract

During the past year, our research included: (1) studies of etiological mechanisms and behaviors associated with individual differences in alcohol consumption in rhesus monkeys; (2) studies of subjects selectively bred for target CSF 5-HIAA; (3) studies of other deficits in subjects with low CSF 5-HIAA; (4) studies of immune correlates of CSF 5-HIAA; (5) studies of treatment of spontaneous self-aggression; (6) studies of effect of rearing on maternal behavior; and (7) development of new technologies to study chronic alcohol consumption.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Type: Intramural Research (Z01)
• Project #: 1Z01AA000277-07
• Application #: 2333291
• Study Section: Special Emphasis Panel (LCS)
• Support Year: 7
• Fiscal Year: 1996

Institution

• Name: National Institute on Alcohol Abuse and Alcoholism
• Country: United States

Publications

Lorenz, Joseph G; Long, Jeffrey C; Linnoila, Markku et al. (2006) Genetic and other contributions to alcohol intake in rhesus macaques (Macaca mulatta). Alcohol Clin Exp Res 30:389-98

Kumar, Rakesh; Perez-Casanova, Antonio E; Tirado, Grissell et al. (2005) Increased viral replication in simian immunodeficiency virus/simian-HIV-infected macaques with self-administering model of chronic alcohol consumption. J Acquir Immune Defic Syndr 39:386-90

Shannon, Courtney; Schwandt, Melanie L; Champoux, Maribeth et al. (2005) Maternal absence and stability of individual differences in CSF 5-HIAA concentrations in rhesus monkey infants. Am J Psychiatry 162:1658-64

Maestripieri, Dario; Lindell, Stephen G; Ayala, Alejandro et al. (2005) Neurobiological characteristics of rhesus macaque abusive mothers and their relation to social and maternal behavior. Neurosci Biobehav Rev 29:51-7

Angeloni, Stephen V; Glynn, Nicole; Ambrosini, Grazia et al. (2004) Characterization of the rhesus monkey ghrelin gene and factors influencing ghrelin gene expression and fasting plasma levels. Endocrinology 145:2197-205

Ayala, Alejandro R; Pushkas, Judy; Higley, J Dee et al. (2004) Behavioral, adrenal, and sympathetic responses to long-term administration of an oral corticotropin-releasing hormone receptor antagonist in a primate stress paradigm. J Clin Endocrinol Metab 89:5729-37

Gustavsson, Gunnar; Traskman-Bendz, Lil; Higley, J Dee et al. (2003) CSF testosterone in 43 male suicide attempters. Eur Neuropsychopharmacol 13:105-9

Bastian, Meredith L; Sponberg, Anne C; Sponberg, Anne C et al. (2003) Long-term effects of infant rearing condition on the acquisition of dominance rank in juvenile and adult rhesus macaques (Macaca mulatta). Dev Psychobiol 42:44-51

Heinz, A; Jones, D W; Gorey, J G et al. (2003) Serotonin transporter availability correlates with alcohol intake in non-human primates. Mol Psychiatry 8:231-4

Anderson, George M; Bennett, Allyson J; Weld, Katherine P et al. (2002) Serotonin in cisternal cerebrospinal fluid of rhesus monkeys: basal levels and effects of sertraline administration. Psychopharmacology (Berl) 161:95-9