Abstract

To identify alcoholism risk genes, we are collecting and testing for linkage families from Indian populations which are relatively homogeneous and in which alcoholism is highly prevalent. This study also addresses the genetic epidemiology and psychiatric comorbidity of alcoholism in Indians. Studies are underway at three sites. Two hundred Cheyenne Indians have been clinically evaluated and their cell lines immortalized. Genetic linkage is underway on this group. At Jemez Pueblo, data and cell lines have been collected for 100 subjects. A study on the Pima Indians is in progress. Frequency of the inactive ALDH and of flushing is low in Cheyenne Indians, as was previously shown by Li et al. for Southwest Pueblo Indians. A synthesis of available population and molecular genetic data indicates a probable role for a selective force (such as a disease) in maintaining the inactive ALDH variant at high frequency in Oriental and South American Indian populations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Intramural Research (Z01)
Project #
1Z01AA000281-01
Application #
3808670
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
National Institute on Alcohol Abuse and Alcoholism
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Landefeld, Clare C; Hodgkinson, Colin A; Spagnolo, Primavera A et al. (2018) Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors. Transl Psychiatry 8:72
Hong, L E; Yang, X; Wonodi, I et al. (2011) A CHRNA5 allele related to nicotine addiction and schizophrenia. Genes Brain Behav 10:530-5
O'Malley, Stephanie S; Robin, Robert W; Levenson, Aryeh L et al. (2008) Naltrexone alone and with sertraline for the treatment of alcohol dependence in Alaska natives and non-natives residing in rural settings: a randomized controlled trial. Alcohol Clin Exp Res 32:1271-83
Ducci, F; Enoch, M-A; Hodgkinson, C et al. (2008) Interaction between a functional MAOA locus and childhood sexual abuse predicts alcoholism and antisocial personality disorder in adult women. Mol Psychiatry 13:334-47
Robin, Robert W; Gottesman, Irving I; Albaugh, Bernard et al. (2007) Schizophrenia and psychotic symptoms in families of two American Indian tribes. BMC Psychiatry 7:30
Barnett, Jennifer H; Heron, Jon; Ring, Susan M et al. (2007) Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children. Am J Psychiatry 164:142-9
Oquendo, Maria A; Hastings, Ramin S; Huang, Yung-Yu et al. (2007) Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Arch Gen Psychiatry 64:201-8
Clarimon, Jordi; Gray, Rebecca R; Williams, Lindsey N et al. (2007) Linkage disequilibrium and association analysis of alpha-synuclein and alcohol and drug dependence in two American Indian populations. Alcohol Clin Exp Res 31:546-54
Yuan, Nicole P; Koss, Mary P; Polacca, Mona et al. (2006) Risk factors for physical assault and rape among six Native American tribes. J Interpers Violence 21:1566-90
Belfer, I; Hipp, H; McKnight, C et al. (2006) Association of galanin haplotypes with alcoholism and anxiety in two ethnically distinct populations. Mol Psychiatry 11:301-11

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