Clinical Immune Survey of the Longitudinal Project Participants

Adler, W H.

Abstract

The immune function of participants in the Baltimore Longitudinal Study of Aging was evaluated to determine age-associated changes, and to relate these changes to clinical disease. Another major goal is to evaluate the ability of existing assays of immune function to provide an accurate assessment of the level of immune competence of aging individuals and to develop new methods and assays to evaluate host immune function.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Intramural Research (Z01)
• Project #: 1Z01AG000104-09
• Application #: 4687894
• Support Year: 9
• Fiscal Year: 1985

Institution

• Name: Aging
• Country: United States

Publications

Lustig, Ana; Carter, Arnell; Bertak, Dorothy et al. (2009) Transcriptome analysis of murine thymocytes reveals age-associated changes in thymic gene expression. Int J Med Sci 6:51-64

Nguyen, Dzung H; Taub, Dennis (2002) Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. Blood 99:4298-306

Nguyen, Dzung H; Taub, Dennis (2002) CXCR4 function requires membrane cholesterol: implications for HIV infection. J Immunol 168:4121-6

Mascarucci, Paolo; Taub, Dennis; Saccani, Simona et al. (2002) Cytokine responses in young and old rhesus monkeys: effect of caloric restriction. J Interferon Cytokine Res 22:565-71

Mascarucci, P; Taub, D; Saccani, S et al. (2001) Age-related changes in cytokine production by leukocytes in rhesus monkeys. Aging (Milano) 13:85-94

Kalehua, A N; Taub, D D; Baskar, P V et al. (2000) Aged mice exhibit greater mortality concomitant to increased brain and plasma TNF-alpha levels following intracerebroventricular injection of lipopolysaccharide. Gerontology 46:115-28

Alexandroff, A B; Jackson, A M; Paterson, T et al. (2000) Role for CD40-CD40 ligand interactions in the immune response to solid tumours. Mol Immunol 37:515-26

Murphy, W J; Funakoshi, S; Fanslow, W C et al. (1999) CD40 stimulation promotes human secondary immunoglobulin responses in HuPBL-SCID chimeras. Clin Immunol 90:22-7

Kirken, R A; Erwin, R A; Taub, D et al. (1999) Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells. J Leukoc Biol 65:891-9

Janik, J E; Miller, L L; Kopp, W C et al. (1999) Treatment with tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor increases epidermal Langerhans' cell numbers in cancer patients. Clin Immunol 93:209-21