Abstract

A method was developed to measure the rate of incorporation of palmitate, Jpalm, from plasma into different brain regions in the awake rat. Jpalm did not change between 3 and 34 months of age, indicating that the rate of turnover of palmitate-containing brain lipids was unchanged. During development of the rat, the time course of Jpalm corresponded to the time course of myelination in the developing brain. Jpalm fell in central auditory pathways following damage to the cochlea. Following a 5 minute period of bilateral ischemia, gerbils had reduced palmitate incorporation into the irreversibly damaged CA 1 region of the hippocampus but increased incorporation into reversibly affected regions. Palmitate incorporation into the hypoglossal nucleus increased maximally 24 days after hypoglossal nerve axotomy. This increase correlated with regenerative processes. Following axotomies in which nerve endings were sealed, palmitate incorporation was decreased at 24-35 days.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000134-05
Application #
3821439
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Ramadan, Epolia; Basselin, Mireille; Taha, Ameer Y et al. (2011) Chronic valproate treatment blocks D2-like receptor-mediated brain signaling via arachidonic acid in rats. Neuropharmacology 61:1256-64
Rapoport, Stanley I; Ramadan, Epolia; Basselin, Mireille (2011) Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. Prostaglandins Other Lipid Mediat 96:109-13
Chang, Lisa; Rapoport, Stanley I; Nguyen, Henry N et al. (2009) Acute nicotine reduces brain arachidonic acid signaling in unanesthetized rats. J Cereb Blood Flow Metab 29:648-58
Basselin, Mireille; Chang, Lisa; Chen, Mei et al. (2008) Chronic administration of valproic acid reduces brain NMDA signaling via arachidonic acid in unanesthetized rats. Neurochem Res 33:2229-40
Basselin, Mireille; Villacreses, Nelly E; Lee, Ho-Joo et al. (2007) Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats. Neurochem Res 32:1857-67
Zapata, Agustin; Gonzales, Rueben A; Shippenberg, Toni S (2006) Repeated ethanol intoxication induces behavioral sensitization in the absence of a sensitized accumbens dopamine response in C57BL/6J and DBA/2J mice. Neuropsychopharmacology 31:396-405
DeMar Jr, James C; Lee, Ho-Joo; Ma, Kaizong et al. (2006) Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats. Biochim Biophys Acta 1761:1050-9
Basselin, Mireille; Chang, Lisa; Rapoport, Stanley I (2006) Chronic lithium chloride administration to rats elevates glucose metabolism in wide areas of brain, while potentiating negative effects on metabolism of dopamine D2-like receptor stimulation. Psychopharmacology (Berl) 187:303-11
Ma, Kaizong; Deutsch, Joseph; Villacreses, Nelly E et al. (2006) Measuring brain uptake and incorporation into brain phosphatidylinositol of plasma myo-[2H6]inositol in unanesthetized rats: an approach to estimate in vivo brain phosphatidylinositol turnover. Neurochem Res 31:759-65
Bhattacharjee, Abesh K; Chang, Lisa; White, Laura et al. (2006) D-Amphetamine stimulates D2 dopamine receptor-mediated brain signaling involving arachidonic acid in unanesthetized rats. J Cereb Blood Flow Metab 26:1378-88

Showing the most recent 10 out of 43 publications