Abstract

of Work: Personality can be defined in terms of enduring individual differences in emotional, interpersonal,experiential, and motivational styles. The five factors of Neuroticism, Extraversion, Openness to Experience, Agreeableness, and Conscientiousness provide a comprehensive taxonomy of personality traits for the description of personality in aging men and women. Collaborative studies of Candian and German samples have confirmed that the five factors are substantially heritable. The robustness of the heritability data for the factors and facets of the Five-Factor Model have encouraged investigators in LPC to attempt to define the genotypic bases of personality.Contrary to prior investigations which showed a link between the personality trait of Novelty-seeking and alleles of the D4 dopamine receptor gene (D4DR), a large-scale study completed this year found no evidence for this association. Another candidate gene relating to a different dimension of personality, Neuroticism, involves a functional polymorphism in the serotonin transporter gene (5-HTT) located on chromosome 17q12(SCL6A4 localization). Over 430 BLSA subjects were genotyped for the long and short variants of the 5-HTT polymorphism. Contrary to the original observation short variants were not higher in Neuroticism.Studies of the molecular genetic bases of personality will continue.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000183-10
Application #
6097794
Study Section
Physiological Chemistry Study Section (PC)
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Seymour, Michelle L; Rajagopalan, Lavanya; Duret, Guillaume et al. (2016) Membrane prestin expression correlates with the magnitude of prestin-associated charge movement. Hear Res 339:50-9
Sun, Deqiang; Luo, Min; Jeong, Mira et al. (2014) Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell 14:673-88
Bagby, R Michael; Quilty, Lena C; Segal, Zindel V et al. (2008) Personality and differential treatment response in major depression: a randomized controlled trial comparing cognitive-behavioural therapy and pharmacotherapy. Can J Psychiatry 53:361-70
McCrae, Robert R; Martin, Thomas A; Hrebickova, Martina et al. (2008) Personality trait similarity between spouses in four cultures. J Pers 76:1137-64
Brummett, Beverly H; Siegler, Ilene C; Day, R Sue et al. (2008) Personality as a predictor of dietary quality in spouses during midlife. Behav Med 34:5-10
Isaacowitz, Derek M; Lockenhoff, Corinna E; Lane, Richard D et al. (2007) Age differences in recognition of emotion in lexical stimuli and facial expressions. Psychol Aging 22:147-59
Terracciano, Antonio; McCrae, Robert R; Costa Jr, Paul T (2006) Longitudinal trajectories in Guilford-Zimmerman temperament survey data: results from the Baltimore longitudinal study of aging. J Gerontol B Psychol Sci Soc Sci 61:P108-16
Terracciano, Antonio; Costa Jr, Paul T; McCrae, Robert R (2006) Personality plasticity after age 30. Pers Soc Psychol Bull 32:999-1009
Costa Jr, Paul T; McCrae, Robert R (2006) Age changes in personality and their origins: comment on Roberts, Walton, and Viechtbauer (2006). Psychol Bull 132:26-8
Pilia, Giuseppe; Chen, Wei-Min; Scuteri, Angelo et al. (2006) Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet 2:e132

Showing the most recent 10 out of 21 publications