Abstract

Consistent with quantitative MRI data, ventricular and sulcal atrophy was significantly greater in older than younger participants, and atrophy was greater in older men than women. Older participants showed more extensive white matter abnormalities than younger participants, and this age difference was similar for men and women. PET imaging studies of regional cerebral blood flow showed that both the verbal and figural recognition memory tasks activate right prefrontal regions, bilateral visua association areas, and left cerebellar regions. Estrogen replacement therapy (ERT) was examined as a risk for Alzheimer~s disease. Approximately 48% of the women in the cohort had used ERT; 34 incident cases of AD were diagnosed during follow-up, including 9 estrogen users. After adjusting for education, the relative risk for AD in ERT users compared to non-users was 0.46 (95% CI=0.209-0.997), indicating a reduced risk of AD for women who had reported the use of estrogen

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000185-07
Application #
2333493
Study Section
Special Emphasis Panel (LPC)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

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Hernandez, Dena G; Nalls, Mike A; Moore, Matthew et al. (2012) Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain. Neurobiol Dis 47:20-8
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Beydoun, May A; Beason-Held, Lori L; Kitner-Triolo, Melissa H et al. (2011) Statins and serum cholesterol's associations with incident dementia and mild cognitive impairment. J Epidemiol Community Health 65:949-57
Rice, S Carrington; Zonderman, Alan B; Metter, E Jeffrey et al. (2009) Absence of relation between depressive symptoms and carotid intimal medial thickness in the Baltimore Longitudinal Study of Aging. Psychosom Med 71:70-6
Beydoun, Hind A; Stadtmauer, Laurel; Beydoun, May A et al. (2009) Polycystic ovary syndrome, body mass index and outcomes of assisted reproductive technologies. Reprod Biomed Online 18:856-63
Szekely, C A; Green, R C; Breitner, J C S et al. (2008) No advantage of A beta 42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies. Neurology 70:2291-8

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