Regulation of Physiological Functions During Aging - Behavioral Biology

Ingram, D K.

Abstract

The purpose of this project is to assess the effects of aging at a behavioral level of analysis, to identify neurobiological mechanisms associated with these effects, and to test interventions that might alter age-related performance decrements. Rodent models are tested in a battery of sensorimotor and learning/memory tasks. Neurochemical and neurohistological assays are conducted to determine neurobiological correlates of functional losses. Interventions include dietary restriction, exercise, various pharmacologic treatments, neurotrophic factors and gene transfer via adenoviral vectors. Multiple genotypes are examined to determine possible genetic involvement in the pattern of age-related behavioral impairment.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Aging (NIA)
• Type: Intramural Research (Z01)
• Project #: 1Z01AG000302-12
• Application #: 5200295
• Support Year: 12
• Fiscal Year: 1995

Institution

• Name: National Institute on Aging
• Country: United States

Publications

Ahmet, Ismayil; Spangler, Edward; Shukitt-Hale, Barbara et al. (2009) Blueberry-enriched diet protects rat heart from ischemic damage. PLoS One 4:e5954

Komatsu, Toshimitsu; Chiba, Takuya; Yamaza, Haruyoshi et al. (2008) Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. Exp Gerontol 43:339-46

Duffy, Kara B; Spangler, Edward L; Devan, Bryan D et al. (2008) A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging 29:1680-9

Devan, Bryan D; Pistell, Paul J; Daffin Jr, Lee W et al. (2007) Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor Nomega-nitro-L-arginine methyl ester. Eur J Pharmacol 563:134-40

Mattison, Julie A; Roth, George S; Lane, Mark A et al. (2007) Dietary restriction in aging nonhuman primates. Interdiscip Top Gerontol 35:137-58

Lane, Mark A; Roth, George S; Ingram, Donald K (2007) Caloric restriction mimetics: a novel approach for biogerontology. Methods Mol Biol 371:143-9

Carlson, Olga; Martin, Bronwen; Stote, Kim S et al. (2007) Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metabolism 56:1729-34

Zou, Sige; Sinclair, Jason; Wilson, Mark A et al. (2007) Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev 128:222-6

O'Neil, Jahn N; Mouton, Peter R; Tizabi, Yousef et al. (2007) Catecholaminergic neuronal loss in locus coeruleus of aged female dtg APP/PS1 mice. J Chem Neuroanat 34:102-7

LE Couteur, David G; Cogger, Victoria C; McCuskey, Robert S et al. (2007) Age-related changes in the liver sinusoidal endothelium: a mechanism for dyslipidemia. Ann N Y Acad Sci 1114:79-87