Abstract

NMR spectroscopy is currently being used at the NIA to study the phosphorus metabolism of peripheral muscle in BLSA subjects and other volunteers, as well as in animals. Age-related and exercise-related effects are under investigation. Methodologic studies to further develop kinetic and spin-lattice relaxation time measurement methodology are also being actively pursued.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000381-04
Application #
3745482
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Bouhrara, Mustapha; Bonny, Jean-Marie; Ashinsky, Beth G et al. (2017) Noise Estimation and Reduction in Magnetic Resonance Imaging Using a New Multispectral Nonlocal Maximum-likelihood Filter. IEEE Trans Med Imaging 36:181-193
Ashinsky, Beth G; Bouhrara, Mustapha; Coletta, Christopher E et al. (2017) Predicting early symptomatic osteoarthritis in the human knee using machine learning classification of magnetic resonance images from the osteoarthritis initiative. J Orthop Res 35:2243-2250
Cameron, Donnie; Bouhrara, Mustapha; Reiter, David A et al. (2017) The effect of noise and lipid signals on determination of Gaussian and non-Gaussian diffusion parameters in skeletal muscle. NMR Biomed 30:
Bouhrara, Mustapha; Reiter, David A; Spencer, Richard G (2015) Bayesian analysis of transverse signal decay with application to human brain. Magn Reson Med 74:785-802
Irrechukwu, Onyi N; Thaer, Sarah Von; Frank, Eliot H et al. (2014) Prediction of cartilage compressive modulus using multiexponential analysis of T(2) relaxation data and support vector regression. NMR Biomed 27:468-77
Reiter, David A; Roque, Remigio A; Lin, Ping-Chang et al. (2011) Improved specificity of cartilage matrix evaluation using multiexponential transverse relaxation analysis applied to pathomimetically degraded cartilage. NMR Biomed 24:1286-94
Lin, Ping-Chang; Reiter, David A; Spencer, Richard G (2009) Classification of degraded cartilage through multiparametric MRI analysis. J Magn Reson 201:61-71
Spencer, Richard G; Calton, Ericka F; Camacho, Nancy Pleshko (2006) Statistical comparison of Fourier transform infrared spectra. J Biomed Opt 11:064023
Baur, Joseph A; Pearson, Kevin J; Price, Nathan L et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444:337-42
Spencer, R F (2006) Removal of acetabular bone in resurfacing arthroplasty of the hip. J Bone Joint Surg Br 88:838

Showing the most recent 10 out of 36 publications