Abstract

Host responses to the HIV are complicated by circulating T cell membrane components such as IL-2R which can interfere with T cell growth and activation signals. Other T cell membrane components such as CD4 can complex to viral envelope proteins, as gp160, along with anti 160 antibody form large complexes. Clinical trials of human growth hormone in normal non-HIV infected individuals have not shown any effects on immune function or granulocyte function. This may be due to the relatively short period of the trials.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000441-04
Application #
3802271
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Giri, Banabihari; Dixit, Vishwa D; Ghosh, Manik C et al. (2007) CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function. Eur J Immunol 37:2104-16
Nguyen, Dzung H; Giri, Banabihari; Collins, Gary et al. (2005) Dynamic reorganization of chemokine receptors, cholesterol, lipid rafts, and adhesion molecules to sites of CD4 engagement. Exp Cell Res 304:559-69
Galey, D; Becker, K; Haughey, N et al. (2003) Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. J Neurovirol 9:358-71
Kalayjian, Robert C; Landay, Alan; Pollard, Richard B et al. (2003) Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes. J Infect Dis 187:1924-33
Zingmond, David S; Kilbourne, Amy M; Justice, Amy C et al. (2003) Differences in symptom expression in older HIV-positive patients: The Veterans Aging Cohort 3 Site Study and HIV Cost and Service Utilization Study experience. J Acquir Immune Defic Syndr 33 Suppl 2:S84-92
Nguyen, Dzung H; Taub, Dennis (2002) Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. Blood 99:4298-306
Nguyen, Dzung H; Taub, Dennis (2002) CXCR4 function requires membrane cholesterol: implications for HIV infection. J Immunol 168:4121-6
Mascarucci, Paolo; Taub, Dennis; Saccani, Simona et al. (2002) Cytokine responses in young and old rhesus monkeys: effect of caloric restriction. J Interferon Cytokine Res 22:565-71
Mascarucci, P; Taub, D; Saccani, S et al. (2001) Age-related changes in cytokine production by leukocytes in rhesus monkeys. Aging (Milano) 13:85-94
Tedla, N; Dwyer, J; Truskett, P et al. (1999) Phenotypic and functional characterization of lymphocytes derived from normal and HIV-1-infected human lymph nodes. Clin Exp Immunol 117:92-9