Abstract

There are many factors which can influence the course of an HIV infection. The most powerful influence is the age of the infected person. Recent studies on the effects of age on immune function and on an HIV infection show that there are age related alterations in host responses with augmentation of the release of inflammatory factors. In an HIV infected individual there is an age related increase in the rate of helper T cell loss which may be due to a decline in the ability to replace HIV destroyed T cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Intramural Research (Z01)
Project #
1Z01AG000441-05
Application #
3789826
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
National Institute on Aging
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Giri, Banabihari; Dixit, Vishwa D; Ghosh, Manik C et al. (2007) CXCL12-induced partitioning of flotillin-1 with lipid rafts plays a role in CXCR4 function. Eur J Immunol 37:2104-16
Nguyen, Dzung H; Giri, Banabihari; Collins, Gary et al. (2005) Dynamic reorganization of chemokine receptors, cholesterol, lipid rafts, and adhesion molecules to sites of CD4 engagement. Exp Cell Res 304:559-69
Galey, D; Becker, K; Haughey, N et al. (2003) Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes. J Neurovirol 9:358-71
Kalayjian, Robert C; Landay, Alan; Pollard, Richard B et al. (2003) Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes. J Infect Dis 187:1924-33
Zingmond, David S; Kilbourne, Amy M; Justice, Amy C et al. (2003) Differences in symptom expression in older HIV-positive patients: The Veterans Aging Cohort 3 Site Study and HIV Cost and Service Utilization Study experience. J Acquir Immune Defic Syndr 33 Suppl 2:S84-92
Nguyen, Dzung H; Taub, Dennis (2002) Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. Blood 99:4298-306
Nguyen, Dzung H; Taub, Dennis (2002) CXCR4 function requires membrane cholesterol: implications for HIV infection. J Immunol 168:4121-6
Mascarucci, Paolo; Taub, Dennis; Saccani, Simona et al. (2002) Cytokine responses in young and old rhesus monkeys: effect of caloric restriction. J Interferon Cytokine Res 22:565-71
Mascarucci, P; Taub, D; Saccani, S et al. (2001) Age-related changes in cytokine production by leukocytes in rhesus monkeys. Aging (Milano) 13:85-94
Tedla, N; Dwyer, J; Truskett, P et al. (1999) Phenotypic and functional characterization of lymphocytes derived from normal and HIV-1-infected human lymph nodes. Clin Exp Immunol 117:92-9