We are studying the molecular biochemistry of gene specific DNA repair and DNA repair coupling with transcription with a view to clarify which gene products are involved and how these processes are regulated as compared to the DNA repair processes in the general, overall bulk of the genome. There are distinct differences in the efficiency of gene- and strand specific DNA repair dependent upon the type of DNA damage, and it is possible that the local degree of chromosomal distortion is the important element in determining the repair response chosen by the cell. We are suggesting that proficient DNA repair is necessary to secure genomic stability, and we find that certain regions of the genome that undergo translocation or rearrangements in the tumor cells are poorly repaired in cells that are susceptible to cancer.
| Bohr, V A (2002) DNA damage and its processing. relation to human disease. J Inherit Metab Dis 25:215-22 |
| Thorslund, Tina; Sunesen, Morten; Bohr, Vilhelm A et al. (2002) Repair of 8-oxoG is slower in endogenous nuclear genes than in mitochondrial DNA and is without strand bias. DNA Repair (Amst) 1:261-73 |
| Rosner, K; Winter, D B; Tarone, R E et al. (2001) Third complementarity-determining region of mutated VH immunoglobulin genes contains shorter V, D, J, P, and N components than non-mutated genes. Immunology 103:179-87 |
| Rosner, K; Winter, D B; Skovgaard, G L et al. (2001) Analysis of microsatellite instability and hypermutation of immunoglobulin variable genes in Werner syndrome. Mech Ageing Dev 122:1121-33 |
