Genetically Controlled Mechanisms of Recovery From Friend Virus-Induced Leukemia

Chesebro, B W.

Abstract

Studies of the mechanisms of genetic control of recovery of adult mice from Friend virus complex (FV)-induced leukemia revealed that the H-2D subregion appeared to influence recovery by altering the kinetics of generation of FV-specific helper T lymphocytes. In addition, gene(s) within the H-2 complex were found to affect the ability of FV to induce immunosuppression to non-retroviral antigens. This resistance to retrovirus-induced immunosuppression occurred in the presence of viremia and persistent leukemic splenomegaly. Furthermore, immunosuppression was not inhibited by the presence of the Rfv-3r/s genotype which enabled certain leukemic mice to mount an effective humoral immune response to FV. Mice with the H-2a/a and Rfv-3r/s genotypes appeared to be similar to AIDS patients in that they made humoral antiviral antibody but were immunosuppressed to challenge with nonviral antigens. Thus, the immune response to viral and nonviral antigens appeared to be influenced by separate host genes in this system. Elucidation of the factors controlling these immune responses should be of value in understanding similar responses in AIDS.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Intramural Research (Z01)
• Project #: 1Z01AI000074-13
• Application #: 4688345
• Support Year: 13
• Fiscal Year: 1985

Institution

• Name: Niaid Extramural Activities
• Country: United States

Publications

Mehaffey, J Hunter; Michaels, Alex D; Mullen, Mathew G et al. (2017) Patient travel for bariatric surgery: does distance matter? Surg Obes Relat Dis 13:2027-2031

Michaels, Alex D; Mullen, Matthew G; Guidry, Christopher A et al. (2017) Unplanned Reoperation Following Colorectal Surgery: Indications and Operations. J Gastrointest Surg 21:1480-1485

Michaels, Alex D; Hunter Mehaffey, J; Brenton French, W et al. (2017) Hypoglycemia Following Bariatric Surgery: Our 31-Year Experience. Obes Surg 27:3118-3123

Mehaffey, J Hunter; Hawkins, Robert B; Mullen, Matthew G et al. (2017) Access to Quaternary Care Surgery: Implications for Accountable Care Organizations. J Am Coll Surg 224:525-529

Mullen, Matthew G; Salerno, Elise P; Michaels, Alex D et al. (2016) Declining Operative Experience for Junior-Level Residents: Is This an Unintended Consequence of Minimally Invasive Surgery? J Surg Educ 73:609-15

Brien, James D; Daffis, Stephane; Lazear, Helen M et al. (2011) Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection. PLoS Pathog 7:e1002230

Peterson, Karin E; Pourciau, Susan; Du, Min et al. (2008) Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain. J Virol 82:8906-10

Santiago, Mario L; Montano, Mauricio; Benitez, Robert et al. (2008) Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321:1343-6

Peterson, K E; Chesebro, B (2006) Influence of proinflammatory cytokines and chemokines on the neuropathogenesis of oncornavirus and immunosuppressive lentivirus infections. Curr Top Microbiol Immunol 303:67-95

Peterson, Karin E; Evans, Leonard H; Wehrly, Kathy et al. (2006) Increased proinflammatory cytokine and chemokine responses and microglial infection following inoculation with neural stem cells infected with polytropic murine retroviruses. Virology 354:143-53