Abstract

1. The role of specific retroviral polytropic envelope sequences in induction of brain disease has been studied in a mouse retroviral model. By infection of neural stem cells with these retroviruses disease induction was enhanced and the pathogenic potential of new envelope gene sequences was revealed. Comparison of two related viral clones has identified two different envelope regions which are important to disease induction. One region appears to influence the amount of viral protein produced and the other appears to influence the toxicity of the protein in infected brain cells. 2. Direct measurement of interferon-gamma in cultures of Friend virus-specific T lymphocytes identified the importance of certain helper T cell subsets in the process of recovery from Friend virus leukemia.3. The mouse Rfv-3 gene, which influences the ability of Friend virus infected mice to make neutralizing antibodies to Friend virus, has been mapped in more detail to a specific 0.8cMregion on chromosome 15. This location is nearby, but distinct from Ly6 and Wnt7b genes but could not be separated from Il2rb, Il3rb and Pdgfb genes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000074-28
Application #
6431512
Study Section
(LPVD)
Project Start
Project End
Budget Start
Budget End
Support Year
28
Fiscal Year
2000
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Mehaffey, J Hunter; Michaels, Alex D; Mullen, Mathew G et al. (2017) Patient travel for bariatric surgery: does distance matter? Surg Obes Relat Dis 13:2027-2031
Michaels, Alex D; Mullen, Matthew G; Guidry, Christopher A et al. (2017) Unplanned Reoperation Following Colorectal Surgery: Indications and Operations. J Gastrointest Surg 21:1480-1485
Michaels, Alex D; Hunter Mehaffey, J; Brenton French, W et al. (2017) Hypoglycemia Following Bariatric Surgery: Our 31-Year Experience. Obes Surg 27:3118-3123
Mehaffey, J Hunter; Hawkins, Robert B; Mullen, Matthew G et al. (2017) Access to Quaternary Care Surgery: Implications for Accountable Care Organizations. J Am Coll Surg 224:525-529
Mullen, Matthew G; Salerno, Elise P; Michaels, Alex D et al. (2016) Declining Operative Experience for Junior-Level Residents: Is This an Unintended Consequence of Minimally Invasive Surgery? J Surg Educ 73:609-15
Brien, James D; Daffis, Stephane; Lazear, Helen M et al. (2011) Interferon regulatory factor-1 (IRF-1) shapes both innate and CD8(+) T cell immune responses against West Nile virus infection. PLoS Pathog 7:e1002230
Peterson, Karin E; Pourciau, Susan; Du, Min et al. (2008) Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain. J Virol 82:8906-10
Santiago, Mario L; Montano, Mauricio; Benitez, Robert et al. (2008) Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321:1343-6
Peterson, K E; Chesebro, B (2006) Influence of proinflammatory cytokines and chemokines on the neuropathogenesis of oncornavirus and immunosuppressive lentivirus infections. Curr Top Microbiol Immunol 303:67-95
Peterson, Karin E; Evans, Leonard H; Wehrly, Kathy et al. (2006) Increased proinflammatory cytokine and chemokine responses and microglial infection following inoculation with neural stem cells infected with polytropic murine retroviruses. Virology 354:143-53

Showing the most recent 10 out of 24 publications