Abstract

This laboratory has been involved in contributing to the development of a malarial vaccine. To this end we have been cloning and characterizing surface antigen genes from the human malarias and have been developing a rodent model system for vaccine testing. Two important contributions with regard to human malarias have been the identification of the immunodominant epitopes of antigens that are dis-played on the surface of the Plasmodial sporozoites of P. vivax and P. malariae. Further, an antigen corresponding to the sporozoite antigens of the human malarias has been identified in a roden malaria. With the goal of developing a rodent model for malaria vaccines, we have immunized mice against parasites and will characterize the degree of protection afforded by the vaccination as well as the B-cell and T-cell responses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000208-06
Application #
3960479
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Oakley, Miranda S; Majam, Victoria; Mahajan, Babita et al. (2009) Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice. PLoS One 4:e6793
Raj, Dipak Kumar; Mu, Jianbing; Jiang, Hongying et al. (2009) Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione. J Biol Chem 284:7687-96
McCutchan, Thomas F (2008) Beyond bed nets. Science 319:33
Oakley, Miranda S; McCutchan, Thomas F; Anantharaman, Vivek et al. (2008) Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. Infect Immun 76:4518-29
Grim, K Christiana; McCutchan, Thomas; Sullivan, Margery et al. (2008) Unidentified Plasmodium species in Australian black swans (Cygnus atratus) hatched and raised in North America. J Zoo Wildl Med 39:216-20
Joy, Deirdre A; Gonzalez-Ceron, Lilia; Carlton, Jane M et al. (2008) Local adaptation and vector-mediated population structure in Plasmodium vivax malaria. Mol Biol Evol 25:1245-52
McCutchan, Thomas F (2008) Is a monkey malaria from Borneo an emerging human disease? Future Microbiol 3:115-8
Li, Jian; Zhang, Yanhui; Sullivan, Margery et al. (2007) Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method. Mol Biochem Parasitol 155:94-102
Oakley, Miranda S M; Kumar, Sanjai; Anantharaman, Vivek et al. (2007) Molecular factors and biochemical pathways induced by febrile temperature in intraerythrocytic Plasmodium falciparum parasites. Infect Immun 75:2012-25
Rathore, Dharmendar; Nagarkatti, Rana; Jani, Dewal et al. (2005) An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion. J Biol Chem 280:20524-9

Showing the most recent 10 out of 29 publications