Abstract

This laboratory has been involved in contributing to the development of a malarial vaccine. To this end we have been characterizing surface antigen genes from Plasmodium falciparum. We have found that variation in the circumsporozoite gene of P. falciparum is likely to be biologically selected because of interaction of the parasite surface molecule wiith host T-cells. We have also studiied the ribosomal RNA of different malarial parasites. Information from these studies has imporatant ramifications for the development of malaria diagnostics, the understanding of evolutionary relationships among the defferent malarial species and the understanding of coontrol of the parasites developomental cycle.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000208-09
Application #
3818137
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Oakley, Miranda S; Majam, Victoria; Mahajan, Babita et al. (2009) Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice. PLoS One 4:e6793
Raj, Dipak Kumar; Mu, Jianbing; Jiang, Hongying et al. (2009) Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione. J Biol Chem 284:7687-96
Joy, Deirdre A; Gonzalez-Ceron, Lilia; Carlton, Jane M et al. (2008) Local adaptation and vector-mediated population structure in Plasmodium vivax malaria. Mol Biol Evol 25:1245-52
McCutchan, Thomas F (2008) Is a monkey malaria from Borneo an emerging human disease? Future Microbiol 3:115-8
McCutchan, Thomas F (2008) Beyond bed nets. Science 319:33
Oakley, Miranda S; McCutchan, Thomas F; Anantharaman, Vivek et al. (2008) Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. Infect Immun 76:4518-29
Grim, K Christiana; McCutchan, Thomas; Sullivan, Margery et al. (2008) Unidentified Plasmodium species in Australian black swans (Cygnus atratus) hatched and raised in North America. J Zoo Wildl Med 39:216-20
Li, Jian; Zhang, Yanhui; Sullivan, Margery et al. (2007) Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method. Mol Biochem Parasitol 155:94-102
Oakley, Miranda S M; Kumar, Sanjai; Anantharaman, Vivek et al. (2007) Molecular factors and biochemical pathways induced by febrile temperature in intraerythrocytic Plasmodium falciparum parasites. Infect Immun 75:2012-25
Rathore, Dharmendar; Nagarkatti, Rana; Jani, Dewal et al. (2005) An immunologically cryptic epitope of Plasmodium falciparum circumsporozoite protein facilitates liver cell recognition and induces protective antibodies that block liver cell invasion. J Biol Chem 280:20524-9

Showing the most recent 10 out of 29 publications