Abstract

Various mouse chromosomal genes alter the susceptibility of mice to retrovirus-induced neoplastic disease. These genes include endogenous retroviral sequences as well as mouse cellular genes which facilitate or restrict virus replication. We have identified a novel common viral integration region associated with tumor induction by type-B leukemogenic retrovirus. This virus is related to mouse mammary tumor virus, but induces T-cell thymic lymphomas. A novel virus integration site was identified in 20% of the tumors screened, suggesting the presence of a functional gene involved in tumor induction. This gene was mapped to a site on the X chromosome not previously known to contain protooncogene sequences. Other experiments were designed to follow the genetic linkage of loci responsible for the clonal deletion of self-Mlsf reactive T cells. Results from these investigations indicated that at least three known MMTV proviruses, Mtv-8, -9, and -11 are responsible for this deletion.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000300-12
Application #
3768770
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Yan, Yuhe; Buckler-White, Alicia; Wollenberg, Kurt et al. (2009) Origin, antiviral function and evidence for positive selection of the gammaretrovirus restriction gene Fv1 in the genus Mus. Proc Natl Acad Sci U S A 106:3259-63
Yan, Yuhe; Kozak, Christine A (2008) Novel postentry resistance to AKV ecotropic mouse gammaretroviruses in the African pygmy mouse, Mus minutoides. J Virol 82:6120-9
Yan, Yuhe; Knoper, Ryan C; Kozak, Christine A (2007) Wild mouse variants of envelope genes of xenotropic/polytropic mouse gammaretroviruses and their XPR1 receptors elucidate receptor determinants of virus entry. J Virol 81:10550-7
Tanaka, Kazuhiro; Tsumaki, Noriyuki; Kozak, Christine A et al. (2006) A Kruppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha2(XI) collage gene. Mol Cell Biol 26:8215-6
Wu, Tiyun; Yan, Yuhe; Kozak, Christine A (2005) Rmcf2, a xenotropic provirus in the Asian mouse species Mus castaneus, blocks infection by polytropic mouse gammaretroviruses. J Virol 79:9677-84
Lee, Suk Keun; Kim, Yeon Sook; Lee, Sang Shin et al. (2004) Molecular cloning, chromosomal mapping, and characteristic expression in tooth organ of rat and mouse Krox-25. Genomics 83:243-53
Jung, Yong Tae; Wu, Tiyun; Kozak, Christine A (2003) Characterization of recombinant nonecotropic murine leukemia viruses from the wild mouse species Mus spretus. J Virol 77:12773-81
Jung, Yong Tae; Kozak, Christine A (2003) Generation of novel syncytium-inducing and host range variants of ecotropic moloney murine leukemia virus in Mus spicilegus. J Virol 77:5065-72
Denicourt, Catherine; Kozak, Christine A; Rassart, Eric (2003) Gris1, a new common integration site in Graffi murine leukemia virus-induced leukemias: overexpression of a truncated cyclin D2 due to alternative splicing. J Virol 77:37-44
Carp, R I; Meeker, H C; Chung, R et al. (2002) Murine leukemia virus in organs of senescence-prone and -resistant mouse strains. Mech Ageing Dev 123:575-84

Showing the most recent 10 out of 32 publications