Cellular Genes Involved in Transformation and Mulv Transmission in Inbred Mice

Kozak, C A.

Abstract

Genetic studies on the transmission of murine retroviruses through the mouse germline, susceptibility to exogenous infection, and virus-induced oncogenesis have led to the identification and chromosomal mapping of numerous genetic loci involved in these phenomena. These studies rely on the analysis of somatic cell hybrids either alone or in conjunction with classical Mendelian crosses. The genes under investigation include proviral integration sites for various mammary tumor viruses and MuLVs, the cellular homologs of several oncogenes, and tumor-associated integration sites. Hybrids have also been used to map several other genes for which cloned probes are available including interferon and Alpha-, Beta-spectrin.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Intramural Research (Z01)
• Project #: 1Z01AI000301-05
• Application #: 3960532
• Support Year: 5
• Fiscal Year: 1986

Institution

• Name: Niaid Extramural Activities
• Country: United States

Publications

Manthey, D; Banach, K; Desplantez, T et al. (2001) Intracellular domains of mouse connexin26 and -30 affect diffusional and electrical properties of gap junction channels. J Membr Biol 181:137-48

Van de Putte, T; Zwijsen, A; Lonnoy, O et al. (2001) Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development. Mech Dev 102:33-44

Wang, L; Yan, L; McGuire, C et al. (2001) Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization. Inflamm Res 50:300-8

Teubner, B; Odermatt, B; Guldenagel, M et al. (2001) Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons. J Neurosci 21:1117-26

Sohl, G; Eiberger, J; Jung, Y T et al. (2001) The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development. Biol Chem 382:973-8

Cinquanta, M; Rovescalli, A C; Kozak, C A et al. (2000) Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos. Proc Natl Acad Sci U S A 97:8904-9

Rovescalli, A C; Cinquanta, M; Ferrante, J et al. (2000) The mouse Nkx-1.2 homeobox gene: alternative RNA splicing at canonical and noncanonical splice sites. Proc Natl Acad Sci U S A 97:1982-7

Akhmedov, N B; Piriev, N I; Chang, B et al. (2000) A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse. Proc Natl Acad Sci U S A 97:5551-6

Teubner, B; Degen, J; Sohl, G et al. (2000) Functional expression of the murine connexin 36 gene coding for a neuron-specific gap junctional protein. J Membr Biol 176:249-62

Caterina, J J; Shi, J; Kozak, C A et al. (2000) Characterization, expression analysis and chromosomal mapping of mouse matrix metalloproteinase-19 (MMP-19). Mol Biol Rep 27:73-9