Abstract

Genetic studies on retrovirus-induced disease and the transmission of infectious virus have led to the identification of numerous chromosomal genes involved in these processes. Genetic mapping of these genes to specific chromosomal loci has been accomplished by the use of somatic cell hybrids alone or in conjunction with classical Mendelian crosses. These studies have now led to the chromosomal mapping of common provirus integration sites found in tumors induced by Gross Passage A MuLV, (Gin-1) Moloney MuLV (Dsi-1) and mouse mammary tumor virus (Int-3). Because these studies have also mapped an increasing number of germline viruses, a revised nomenclature system was derised for one group of endogenous retroviruses, the MMTVs. Use of hybrid cells also permitted the identification of the Bxv-1 provirus and implicated this provirus in the formation of the leukemogenic MCF MuLV. Finally, cell hybrids have been increasingly used to chromosomally map other genes for which cloned probes are available including an interferon receptor, interleukin-3 and the oncogenes Draf, Ets, Rel, and Mbcl-2.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000301-07
Application #
3822031
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Teubner, B; Odermatt, B; Guldenagel, M et al. (2001) Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons. J Neurosci 21:1117-26
Sohl, G; Eiberger, J; Jung, Y T et al. (2001) The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development. Biol Chem 382:973-8
Manthey, D; Banach, K; Desplantez, T et al. (2001) Intracellular domains of mouse connexin26 and -30 affect diffusional and electrical properties of gap junction channels. J Membr Biol 181:137-48
Van de Putte, T; Zwijsen, A; Lonnoy, O et al. (2001) Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development. Mech Dev 102:33-44
Wang, L; Yan, L; McGuire, C et al. (2001) Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization. Inflamm Res 50:300-8
Teubner, B; Degen, J; Sohl, G et al. (2000) Functional expression of the murine connexin 36 gene coding for a neuron-specific gap junctional protein. J Membr Biol 176:249-62
Caterina, J J; Shi, J; Kozak, C A et al. (2000) Characterization, expression analysis and chromosomal mapping of mouse matrix metalloproteinase-19 (MMP-19). Mol Biol Rep 27:73-9
Chen, C; Kim, M G; Soo Lyu, M et al. (2000) Characterization of the mouse gene, human promoter and human cDNA of TSCOT reveals strong interspecies homology. Biochim Biophys Acta 1493:159-69
Korthauer, U; Nagel, W; Davis, E M et al. (2000) Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family. J Immunol 164:308-18
Cinquanta, M; Rovescalli, A C; Kozak, C A et al. (2000) Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos. Proc Natl Acad Sci U S A 97:8904-9

Showing the most recent 10 out of 29 publications