Cellular Genes Involved in Transformation and Mulv Transmission in Inbred Mice

Kozak, C A.

Abstract

Numerous chromosomal gene shave been identified which are involved in retrovirus-induced disease and the transmission of retroviral genes in the inbred mouse. Genetic mapping of these genes to specific mouse chromosomes has been accomplished by the analysis of Chinese hamster x mouse somatic cell hybrids each of which contains different mouse chromosomes. In some cases, genes have also been mapped to subchromosomal regions or to specific map locations along these chromosomes by use of classical Mendelian crosses. These studies have led to chromosomal mapping of genes encoding the tumor rejection antigen gp96, the Fms and Met proto- oncogenes and a sequence which may represent the ecotropic MuLV cell surface receptor. The somatic cell hybrids have also been used to map other chromosomal gene for which cloned probes are available. Most recently, we have mapped genes for spermatid associated proteins, genes related to Drosophila heat shock proteins, P450 cytochromes, and several T lymphocyte antigens.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Intramural Research (Z01)
• Project #: 1Z01AI000301-08
• Application #: 3818178
• Support Year: 8
• Fiscal Year: 1988

Institution

• Name: Niaid Extramural Activities
• Country: United States

Publications

Manthey, D; Banach, K; Desplantez, T et al. (2001) Intracellular domains of mouse connexin26 and -30 affect diffusional and electrical properties of gap junction channels. J Membr Biol 181:137-48

Van de Putte, T; Zwijsen, A; Lonnoy, O et al. (2001) Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development. Mech Dev 102:33-44

Wang, L; Yan, L; McGuire, C et al. (2001) Mouse histamine N-methyltransferase: cDNA cloning, expression, gene cloning and chromosomal localization. Inflamm Res 50:300-8

Teubner, B; Odermatt, B; Guldenagel, M et al. (2001) Functional expression of the new gap junction gene connexin47 transcribed in mouse brain and spinal cord neurons. J Neurosci 21:1117-26

Sohl, G; Eiberger, J; Jung, Y T et al. (2001) The mouse gap junction gene connexin29 is highly expressed in sciatic nerve and regulated during brain development. Biol Chem 382:973-8

Teubner, B; Degen, J; Sohl, G et al. (2000) Functional expression of the murine connexin 36 gene coding for a neuron-specific gap junctional protein. J Membr Biol 176:249-62

Caterina, J J; Shi, J; Kozak, C A et al. (2000) Characterization, expression analysis and chromosomal mapping of mouse matrix metalloproteinase-19 (MMP-19). Mol Biol Rep 27:73-9

Chen, C; Kim, M G; Soo Lyu, M et al. (2000) Characterization of the mouse gene, human promoter and human cDNA of TSCOT reveals strong interspecies homology. Biochim Biophys Acta 1493:159-69

Korthauer, U; Nagel, W; Davis, E M et al. (2000) Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family. J Immunol 164:308-18

Cinquanta, M; Rovescalli, A C; Kozak, C A et al. (2000) Mouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryos. Proc Natl Acad Sci U S A 97:8904-9