Studies of Acquired Immune Deficiency Syndrome

Purcell, R H.

Abstract

A new medical syndrome, Acquired Immune Deficiency Syndrome (AIDS) has recently been recognized. It is characterized by profound progressive depression of the immune system, resulting in repeated opportunistic infections and at least one type of neoplasm. The syndrome is usually if not always fatal. A retrovirus has been identified as the etiologic agent of AIDS. Attempts to develop a suitable primate animal model are in progress.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Intramural Research (Z01)
• Project #: 1Z01AI000370-04
• Application #: 3960575
• Support Year: 4
• Fiscal Year: 1986

Institution

• Name: Niaid Extramural Activities
• Country: United States

Publications

Sanders-Beer, Brigitte E; Eschricht, Magdalena; Seifried, Janna et al. (2012) Characterization of a monoclonal anti-capsid antibody that cross-reacts with three major primate lentivirus lineages. Virology 422:402-12

Kuwata, Takeo; Nishimura, Yoshiaki; Whitted, Sonya et al. (2009) Association of progressive CD4(+) T cell decline in SIV infection with the induction of autoreactive antibodies. PLoS Pathog 5:e1000372

Dang, Que; Goeken, Robert M; Brown, Charles R et al. (2008) Adaptive evolution of simian immunodeficiency viruses isolated from 2 conventional-progressor macaques with encephalitis. J Infect Dis 197:1695-700

Gautam, Rajeev; Carter, Anders Chase; Katz, Nathalia et al. (2007) In vitro characterization of primary SIVsmm isolates belonging to different lineages. In vitro growth on rhesus macaque cells is not predictive for in vivo replication in rhesus macaques. Virology 362:257-70

Nishimura, Yoshiaki; Igarashi, Tatsuhiko; Buckler-White, Alicia et al. (2007) Loss of naive cells accompanies memory CD4+ T-cell depletion during long-term progression to AIDS in Simian immunodeficiency virus-infected macaques. J Virol 81:893-902

Brown, Charles R; Czapiga, Meggan; Kabat, Juraj et al. (2007) Unique pathology in simian immunodeficiency virus-infected rapid progressor macaques is consistent with a pathogenesis distinct from that of classical AIDS. J Virol 81:5594-606

Kuwata, Takeo; Byrum, Russell; Whitted, Sonya et al. (2007) A rapid progressor-specific variant clone of simian immunodeficiency virus replicates efficiently in vivo only in the absence of immune responses. J Virol 81:8891-904

Pandrea, Ivona; Apetrei, Cristian; Gordon, Shari et al. (2007) Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts. Blood 109:1069-76

Kuwata, Takeo; Dehghani, Houman; Brown, Charles R et al. (2006) Infectious molecular clones from a simian immunodeficiency virus-infected rapid-progressor (RP) macaque: evidence of differential selection of RP-specific envelope mutations in vitro and in vivo. J Virol 80:1463-75

Pandrea, Ivona; Silvestri, Guido; Onanga, Richard et al. (2006) Simian immunodeficiency viruses replication dynamics in African non-human primate hosts: common patterns and species-specific differences. J Med Primatol 35:194-201