Abstract

Ivermectin has been shown in trials in both South India and elsewhere to be very effective in clearing microfilaremia in patients with bancroftian filariasis. Current studies in South India and Brazil (coordinated with trail elsewhere in the world) are focussed on developing a regimen to optimize the duration of microfilarial clearance. Recent investigation has indicated that the Tropical Pulmonary Eosinophilia syndrome can be caused by strongyloides as well as by filariae. Work to differentiate these two pulmonary eosinophilic conditions and develop appropriate therapy is underway. Loiasis in expatriate visitors to endemic areas has been characterized as having marked clinical and immunologic hyperresponsiveness to the filarial parasite. The hypothesized state of hyporesponsiveness, both clinical and immunological, in infected individuals native to the endemic regions has now been demonstrated by studies in Benin, West Africa. A therapeutic trial of albendazole for loiasis is also underway there.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000439-07
Application #
3803184
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Cirino, Christopher M; Leitman, Susan F; Williams, Esther et al. (2008) Transfusion-associated babesiosis with an atypical time course after nonmyeloablative transplantation for sickle cell disease. Ann Intern Med 148:794-5
Frances, Stephen P; Baade, Lisa M; Kubofcik, Joseph et al. (2008) Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste. Am J Trop Med Hyg 78:560-3
Kim, Yae-Jean; Dale, Janet K; Noel, Pierre et al. (2007) Eosinophilia is associated with a higher mortality rate among patients with autoimmune lymphoproliferative syndrome. Am J Hematol 82:615-24
Klion, Amy D; Robyn, Jamie; Maric, Irina et al. (2007) Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing. Blood 110:3552-6
Maric, Irina; Robyn, Jamie; Metcalfe, Dean D et al. (2007) KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities. J Allergy Clin Immunol 120:680-7
Lipner, Ettie M; Law, Melissa A; Barnett, Elizabeth et al. (2007) Filariasis in Travelers Presenting to the GeoSentinel Surveillance Network. PLoS Negl Trop Dis 1:e88
Dicko, Alassane; Sagara, Issaka; Diemert, David et al. (2007) Year-to-year variation in the age-specific incidence of clinical malaria in two potential vaccine testing sites in Mali with different levels of malaria transmission intensity. Am J Trop Med Hyg 77:1028-33
Klion, Amy D (2007) Approach to the therapy of hypereosinophilic syndromes. Immunol Allergy Clin North Am 27:551-60
Nutman, Thomas B (2007) Evaluation and differential diagnosis of marked, persistent eosinophilia. Immunol Allergy Clin North Am 27:529-49
Lipner, Ettie M; Gopi, P G; Subramani, R et al. (2006) Coincident filarial, intestinal helminth, and mycobacterial infection: helminths fail to influence tuberculin reactivity, but BCG influences hookworm prevalence. Am J Trop Med Hyg 74:841-7

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