Abstract

To understand better the pathogenesis of filarial infections (onchocerciasis, loiaisis, lymphatic filarasis) clinical assessments of patients with these and other related non-filarial (strongyloides, malaria) infections have been studied in detail. Moreover, the post-treatment inflammatory responses and the underlying mechanisms in their induction have been detailed. In particular, the control of eosinophil induction and cell trafficking to sites of post-treatment inflammation has been studied. The importance of the Wolbachia endosymbiont both as a therapeutic target and as a inducer of inflammation has been detailed as well. In FY 2003, we demonstrated the relative paucity of adverse reactions seen following ivermectin/albendazole treatment of lymphatic filariasis in Mali and have shown that co-infection with Mansonella perstans does little to alter the post-treatment reactions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000439-20
Application #
6985593
Study Section
(LPD)
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
2004
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Cirino, Christopher M; Leitman, Susan F; Williams, Esther et al. (2008) Transfusion-associated babesiosis with an atypical time course after nonmyeloablative transplantation for sickle cell disease. Ann Intern Med 148:794-5
Frances, Stephen P; Baade, Lisa M; Kubofcik, Joseph et al. (2008) Seroconversion to filarial antigens in Australian defence force personnel in Timor-Leste. Am J Trop Med Hyg 78:560-3
Kim, Yae-Jean; Dale, Janet K; Noel, Pierre et al. (2007) Eosinophilia is associated with a higher mortality rate among patients with autoimmune lymphoproliferative syndrome. Am J Hematol 82:615-24
Klion, Amy D; Robyn, Jamie; Maric, Irina et al. (2007) Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing. Blood 110:3552-6
Maric, Irina; Robyn, Jamie; Metcalfe, Dean D et al. (2007) KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities. J Allergy Clin Immunol 120:680-7
Lipner, Ettie M; Law, Melissa A; Barnett, Elizabeth et al. (2007) Filariasis in Travelers Presenting to the GeoSentinel Surveillance Network. PLoS Negl Trop Dis 1:e88
Dicko, Alassane; Sagara, Issaka; Diemert, David et al. (2007) Year-to-year variation in the age-specific incidence of clinical malaria in two potential vaccine testing sites in Mali with different levels of malaria transmission intensity. Am J Trop Med Hyg 77:1028-33
Klion, Amy D (2007) Approach to the therapy of hypereosinophilic syndromes. Immunol Allergy Clin North Am 27:551-60
Nutman, Thomas B (2007) Evaluation and differential diagnosis of marked, persistent eosinophilia. Immunol Allergy Clin North Am 27:529-49
McPherson, T; Persaud, S; Singh, S et al. (2006) Interdigital lesions and frequency of acute dermatolymphangioadenitis in lymphoedema in a filariasis-endemic area. Br J Dermatol 154:933-41

Showing the most recent 10 out of 40 publications