Abstract

A productive infection by vaccinia virus involves entry into the cell, expression and replication of the genome and assembly and release of infectious, enveloped, virus particles. Many of these steps involve interactions of viral proteins with cellular proteins or membranes. Combined genetic, biochemical, and electron microscopic approaches are being used to investigate these complex processes. During the past year, emphasis has been on understanding the steps in the formation and transmission of intracellular and extracellular virions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000539-19
Application #
7300005
Study Section
(LVD)
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Wagenaar, Timothy R; Moss, Bernard (2009) Expression of the A56 and K2 proteins is sufficient to inhibit vaccinia virus entry and cell fusion. J Virol 83:1546-54
Resch, Wolfgang; Weisberg, Andrea S; Moss, Bernard (2009) Expression of the highly conserved vaccinia virus E6 protein is required for virion morphogenesis. Virology 386:478-85
Nelson, Gretchen E; Wagenaar, Timothy R; Moss, Bernard (2008) A conserved sequence within the H2 subunit of the vaccinia virus entry/fusion complex is important for interaction with the A28 subunit and infectivity. J Virol 82:6244-50
Wagenaar, Timothy R; Ojeda, Suany; Moss, Bernard (2008) Vaccinia virus A56/K2 fusion regulatory protein interacts with the A16 and G9 subunits of the entry fusion complex. J Virol 82:5153-60
Wagenaar, Timothy R; Moss, Bernard (2007) Association of vaccinia virus fusion regulatory proteins with the multicomponent entry/fusion complex. J Virol 81:6286-93
Husain, Matloob; Weisberg, Andrea S; Moss, Bernard (2007) Resistance of a vaccinia virus A34R deletion mutant to spontaneous rupture of the outer membrane of progeny virions on the surface of infected cells. Virology 366:424-32
Charity, James C; Katz, Ehud; Moss, Bernard (2007) Amino acid substitutions at multiple sites within the vaccinia virus D13 scaffold protein confer resistance to rifampicin. Virology 359:227-32
Townsley, Alan C; Moss, Bernard (2007) Two distinct low-pH steps promote entry of vaccinia virus. J Virol 81:8613-20
Resch, Wolfgang; Hixson, Kim K; Moore, Ronald J et al. (2007) Protein composition of the vaccinia virus mature virion. Virology 358:233-47
Husain, Matloob; Weisberg, Andrea S; Moss, Bernard (2007) Sequence-independent targeting of transmembrane proteins synthesized within vaccinia virus factories to nascent viral membranes. J Virol 81:2646-55

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