Our research program continues to focus on three broad areas. These encompass: I) Molecular Regulation of HIV-1; II) Molecular Regulation of HTLV-I; and III) Molecular applications relevant for the development of HIV-1 specific ribozymes and transdominant/attenuated human immunodeficiency viruses. Here I summarize our progress over the past year. A more detailed visualization of our research is reflected in our annual bibliography. In brief, our research in 1994-1995 are described with the following 11 points. Recent selected findings include: 1) progress in understanding the modulation of Sp1 phosphorylation by HIV-1 Tat; 2) the in vivo selection of Tat mutants through forced high passage of recombinant HIV-1 genomes containing insertion of a Tat cDNA into nef; 3) the demonstration of a physical interaction between HIV-1 Tat and cellular protein kinase, PKR; 4) the characterization of a cellular function for TAR-RNA-binding protein, TRBP; 5) the discovery of a physical interaction between secreted Tat protein and cellular growth factor, epithelin; 6) the development of chimeric HIV-1 and SIVmac nef- HSVtk+ viruses as possible viral vaccine strains; 7) the optimization of semliki forest virus as an anti-HIV-1 ribozyme vector; 8) the isolation and characterization of cDNAs that encode cellular proteins that bind to HTLV-I Tax using the yeast two hybrid system; 9) the definition of a novel repressive effect of HTLV-I Tax on the c-myc oncoprotein; 10) the subnuclear localization of the HTLV-I Tax protein using confocal microscopy; 11) the characterization of differences between HTLV-I and -II Tax proteins in the induction of micronuclei.
| Yeung, Man Lung; Houzet, Laurent; Yedavalli, Venkat S R K et al. (2009) A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. J Biol Chem 284:19463-73 |
| Yeung, Man Lung; Bennasser, Yamina; Watashi, Koichi et al. (2009) Pyrosequencing of small non-coding RNAs in HIV-1 infected cells: evidence for the processing of a viral-cellular double-stranded RNA hybrid. Nucleic Acids Res 37:6575-86 |
| Grassmann, Ralph; Jeang, Kuan-Teh (2008) The roles of microRNAs in mammalian virus infection. Biochim Biophys Acta : |
| Jeang, Kuan-Teh (2007) World AIDS Day 2007: AIDS at 26, are we there yet? Retrovirology 4:86 |
| Lee, Jia Hai; Yedavalli, Venkat Rk; Jeang, Kuan-Teh (2007) Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-beta (PKG1beta). Retrovirology 4:91 |
| Berkhout, Ben; Jeang, Kuan-Teh (2007) RISCy business: MicroRNAs, pathogenesis, and viruses. J Biol Chem 282:26641-5 |
| Yeung, Man Lung; Bennasser, Yamina; Le, Shu-Yun et al. (2007) RNA interference and HIV-1. Adv Pharmacol 55:427-38 |
| Yeung, Man Lung; Benkirane, Monsef; Jeang, Kuan-Teh (2007) Small non-coding RNAs, mammalian cells, and viruses: regulatory interactions? Retrovirology 4:74 |
| Yedavalli, Venkat R K; Jeang, Kuan-Teh (2007) Methylation: a regulator of HIV-1 replication? Retrovirology 4:9 |
| Triboulet, Robinson; Mari, Bernard; Lin, Yea-Lih et al. (2007) Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science 315:1579-82 |
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