Abstract

Studies have demonstrated that intermittent infusions of the T cell derived cytokine IL-2 can lead to profound increases in the size of the CD4+ pool. An analysis of the IL-7/IL-7 receptor (CD127) system revealed that CD127 expression on T cells was low and remained low in HIV-infected patients despite antiretroviral or IL-2 therapy, reflecting persistent aberration in the subset composition of the T-cell pool. In another study, contrary to prior reports, treatment of helminthic infection did not lead to a decrease in levels of HIV replication indicating the complex nature of the relationships between HIV infection immune activation and secondary infections.? ? In other work, a novel series of mutations were noted in a patient with high-level resistance to HIV protease inhibitors. These mutations involved changes in the binding site, the cleavage site and in areas controlling overall replication competence. Finally, the paradoxical ability of Actinomycin D to increase HIV replication was found to be due to the induction of IL-6.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000585-17
Application #
7301883
Study Section
(CMR)
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
2006
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Porter, Brian O; Shen, Jean; Kovacs, Joseph A et al. (2009) Interleukin-2 cycling causes transient increases in high-sensitivity C-reactive protein and D-dimer that are not associated with plasma HIV-RNA levels. AIDS 23:2015-9
Sereti, Irini; Sklar, Peter; Ramchandani, Meena S et al. (2007) CD4+ T cell responses to interleukin-2 administration in HIV-infected patients are directly related to the baseline level of immune activation. J Infect Dis 196:677-83
Nishimura, Yoshiaki; Igarashi, Tatsuhiko; Buckler-White, Alicia et al. (2007) Loss of naive cells accompanies memory CD4+ T-cell depletion during long-term progression to AIDS in Simian immunodeficiency virus-infected macaques. J Virol 81:893-902
Sakamoto, Norihisa; Tsuji, Kazuhide; Muul, Linda M et al. (2007) Bovine apolipoprotein B-100 is a dominant immunogen in therapeutic cell populations cultured in fetal calf serum in mice and humans. Blood 110:501-8
Igarashi, Tatsuhiko; Iyengar, Ranjini; Byrum, Russel A et al. (2007) Human immunodeficiency virus type 1 derivative with 7% simian immunodeficiency virus genetic content is able to establish infections in pig-tailed macaques. J Virol 81:11549-52
Read, Sarah W; Higgins, Jeanette; Metcalf, Julia A et al. (2006) Decreased CD127 expression on T Cells in HIV-1-infected adults receiving antiretroviral therapy with or without intermittent IL-2 therapy. J Acquir Immune Defic Syndr 42:537-44
Brann, Terrence W; Dewar, Robin L; Jiang, Min-Kan et al. (2006) Functional correlation between a novel amino acid insertion at codon 19 in the protease of human immunodeficiency virus type 1 and polymorphism in the p1/p6 Gag cleavage site in drug resistance and replication fitness. J Virol 80:6136-45
Lempicki, R A; Polis, M A; Yang, J et al. (2006) Gene expression profiles in hepatitis C virus (HCV) and HIV coinfection: class prediction analyses before treatment predict the outcome of anti-HCV therapy among HIV-coinfected persons. J Infect Dis 193:1172-7
Youle, Mike; Emery, Sean; Fisher, Martin et al. (2006) A Randomised Trial of Subcutaneous Intermittent Interleukin-2 without Antiretroviral Therapy in HIV-Infected Patients: The UK-Vanguard Study. PLoS Clin Trials 1:e3
Keh, Chris E; Shen, Jean M; Hahn, Barbara et al. (2006) Interruption of antiretroviral therapy blunts but does not abrogate CD4 T-cell responses to interleukin-2 administration in HIV infected patients. AIDS 20:361-9

Showing the most recent 10 out of 38 publications