Abstract

Hypereosinophilic conditions have been studied extensively, and we have identified new markers that distinguish between a myeloproliferative and a lymphoproliferative form of the Hyperosinophilic Syndrome. Having made this distinction, we have instituted new therapies for the treatment of each of these forms. The interaction between helminth infection and allergic disease has been studied using epidemiological tools coupled with physiological measurements of allergic disease and immunological assessments. We have demonstrated that chronic helminth infection protects against allergic diseases.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000805-07
Application #
6808856
Study Section
(HIS)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Klion, Amy (2009) Hypereosinophilic syndrome: current approach to diagnosis and treatment. Annu Rev Med 60:293-306
Klion, Amy D (2009) How I treat hypereosinophilic syndromes. Blood 114:3736-41
Cooper, Philip J; Mitre, Edward; Moncayo, Ana Lucia et al. (2008) Ascaris lumbricoides-induced interleukin-10 is not associated with atopy in schoolchildren in a rural area of the tropics. J Infect Dis 197:1333-40
Kim, Yae-Jean; Dale, Janet K; Noel, Pierre et al. (2007) Eosinophilia is associated with a higher mortality rate among patients with autoimmune lymphoproliferative syndrome. Am J Hematol 82:615-24
Klion, Amy D; Robyn, Jamie; Maric, Irina et al. (2007) Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing. Blood 110:3552-6
Maric, Irina; Robyn, Jamie; Metcalfe, Dean D et al. (2007) KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities. J Allergy Clin Immunol 120:680-7
Nutman, Thomas B (2007) Evaluation and differential diagnosis of marked, persistent eosinophilia. Immunol Allergy Clin North Am 27:529-49
Robyn, Jamie; Lemery, Steven; McCoy, J Philip et al. (2006) Multilineage involvement of the fusion gene in patients with FIP1L1/PDGFRA-positive hypereosinophilic syndrome. Br J Haematol 132:286-92
Mitre, Edward; Nutman, Thomas B (2006) IgE memory: persistence of antigen-specific IgE responses years after treatment of human filarial infections. J Allergy Clin Immunol 117:939-45
Kim, Yae-Jean; Nutman, Thomas B (2006) Eosinophilia: causes and pathobiology in persons with prior exposures in tropical areas with an emphasis on parasitic infections. Curr Infect Dis Rep 8:43-50

Showing the most recent 10 out of 41 publications