Abstract

The specialty field of laboratory animal medicine and care covers a diverse array of responsibilities. Comparative Medicine Branch (CMB) staff may encounter unusual clinical cases and emerging murine infectious diseases during their normal work duties that are conducive to study. The construction and management of facilities for human emerging diseases and potential bioterrorism agent research also results in unique experiences. Publication of these findings and experiences contributes to advancing the laboratory animal field's body of knowledge, which may consequently result in: decreased confounding variables within animal studies; information about clinical changes observed in animals i.e. are the changes due to research use or are they a spontaneous problem?; and decreased cost for other entities that decide to build facilities to study emerging diseases and bioterrorism agents. Adventitious murine norovirus (MNV) and Spironucleus muris infections identified in research mouse colonies were studied. MNV is an emerging viral contaminant of mice with the potential to confound immunology research. S. muris is a protozoan rarely found in rodent colonies; it is also reported to confound immunology research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI001047-01
Application #
7732695
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2008
Total Cost
$17,073,377
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Oakley, Miranda S; Majam, Victoria; Mahajan, Babita et al. (2009) Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice. PLoS One 4:e6793
Maximova, Olga A; Faucette, Lawrence J; Ward, Jerrold M et al. (2009) Cellular inflammatory response to flaviviruses in the central nervous system of a primate host. J Histochem Cytochem 57:973-89
Liu, Qi; Cheng, Lily I; Yi, Liang et al. (2009) p47phox deficiency induces macrophage dysfunction resulting in progressive crystalline macrophage pneumonia. Am J Pathol 174:153-63
Collin, Nicolas; Gomes, Regis; Teixeira, Clarissa et al. (2009) Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for Leishmania. PLoS Pathog 5:e1000441
Gozalo, Alfonso S; Rosenberg, Helene F; Elkins, William R et al. (2009) Multisystemic eosinophilia resembling hypereosinophilic syndrome in a colony-bred owl monkey (Aotus vociferans). J Am Assoc Lab Anim Sci 48:303-6
Reines, Brandon; Cheng, Lily I; Matzinger, Polly (2009) Unexpected regeneration in middle-aged mice. Rejuvenation Res 12:45-52
Lim, Jean K; Lisco, Andrea; McDermott, David H et al. (2009) Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man. PLoS Pathog 5:e1000321
Buchholz, Ursula J; Ward, Jerrold M; Lamirande, Elaine W et al. (2009) Deletion of nonstructural proteins NS1 and NS2 from pneumonia virus of mice attenuates viral replication and reduces pulmonary cytokine expression and disease. J Virol 83:1969-80
Moayeri, Mahtab; Crown, Devorah; Dorward, David W et al. (2009) The heart is an early target of anthrax lethal toxin in mice: a protective role for neuronal nitric oxide synthase (nNOS). PLoS Pathog 5:e1000456
Fain, Michelle A; Karjala, Zuzana; Perdue, Kathy A et al. (2008) Detection of Spironucleus muris in unpreserved mouse tissue and fecal samples by using a PCR assay. J Am Assoc Lab Anim Sci 47:39-43

Showing the most recent 10 out of 16 publications