MPDP+ has been recognized to be an intermediary metabolite in the conversion of MPTP into MPP+. MPDP+ disproportionates at physiological pH into MPTP and MPP+. MPTP, MPDP+ and MPP+ are inhibitors of monoamineoxidase B, and all three inhibit dopamine uptake in rat synaptosomal preparations. New synthesis of MPDP+ were developed and analogs of MPTP with the phenyl group at different positions of the tetrahydropyridine ring, and with N-alkyl groups instead of an N-methyl group were prepared. The biological effects demonstrated by MPTP were not shown by any of its analogs prepared thus far.

Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Arthritis, Diabetes, Digestive & Kid Dis
Department
Type
DUNS #
City
State
Country
United States
Zip Code