A large number of patients with both neoplastic and non-neoplastic inappropriate secretion of thyrotropin have been investigated. Fibroblasts from patients with generalized thyroid hormone resistance display abnormal kinetics of triiodothyronine nuclear uptake. Thyroid hormone and thyrotropin-releasing hormone regulate the bioactivity of thyrotropin. The carbohydrate of thyrotropin is not essential for receptor binding but is necessary for receptor coupling to adenylate cyclase.

Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Arthritis, Diabetes, Digestive & Kid Dis
Department
Type
DUNS #
City
State
Country
United States
Zip Code