Abstract

Less than 1% of the total body magnesium is present in the peripheral blood. We developed an assay to determine the magnesium content of blood mononuclear cells which did not correlate with either the plasma or erythrocyte magnesium concentrations. The blood mononuclear cell magnesium concentration may be a better predictor of intracellular magnesium content and/or total body magnesium status than either plasma or erythrocyte magnesium concentrations. In addition, we developed a method using the electron probe to quantify the magnesium content of individual lymphocytes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010010-10
Application #
4692026
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Lane, Jason W; Rehak, Nadja N; Hortin, Glen L et al. (2008) Pseudohyperphosphatemia associated with high-dose liposomal amphotericin B therapy. Clin Chim Acta 387:145-9
Haddad, Salim; Leitman, Susan F; Wesley, Robert A et al. (2005) Placebo-controlled study of intravenous magnesium supplementation during large-volume leukapheresis in healthy allogeneic donors. Transfusion 45:934-44
Bolan, Charles D; Yau, Yu Ying; Cullis, Herbert C et al. (2004) Pediatric large-volume leukapheresis: a single institution experience with heparin versus citrate-based anticoagulant regimens. Transfusion 44:229-38
Bolan, Charles D; Wesley, Robert A; Yau, Yu Ying et al. (2003) Randomized placebo-controlled study of oral calcium carbonate administration in plateletpheresis: I. Associations with donor symptoms. Transfusion 43:1403-13
Bolan, Charles D; Cecco, Stacey A; Yau, Yu Ying et al. (2003) Randomized placebo-controlled study of oral calcium carbonate supplementation in plateletpheresis: II. Metabolic effects. Transfusion 43:1414-22
Bolan, Charles D; Cecco, Stacey A; Wesley, Robert A et al. (2002) Controlled study of citrate effects and response to i.v. calcium administration during allogeneic peripheral blood progenitor cell donation. Transfusion 42:935-46
McKee, Mark D; Cecco, Stacey A; Niemela, Julie E et al. (2002) Effects of interleukin 2 therapy on lymphocyte magnesium levels. J Lab Clin Med 139:5-12
Bolan, C D; Greer, S E; Cecco, S A et al. (2001) Comprehensive analysis of citrate effects during plateletpheresis in normal donors. Transfusion 41:1165-71