Abstract

Less than 1% of the total body magnesium is present in the peripheral blood. We developed assays to determine the magnesium content and concentration of mononuclear blood cells as a potential index for intracellular magnesium and/or total body magnesium status. Patients with a surgical cure of hyperparathyroidism show a significant increase in the magnesium concentration of red blood cells and the magnesium content of mononuclear blood cells. Patients with hypoparathyroidism have a significant elevation of magnesium in red blood cells and mononuclear blood cells compared with normal individuals. Further, intravenous infusion of magnesium acutely effects a significant increase in the magnesium content of mononuclear blood cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010010-17
Application #
3837974
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Lane, Jason W; Rehak, Nadja N; Hortin, Glen L et al. (2008) Pseudohyperphosphatemia associated with high-dose liposomal amphotericin B therapy. Clin Chim Acta 387:145-9
Haddad, Salim; Leitman, Susan F; Wesley, Robert A et al. (2005) Placebo-controlled study of intravenous magnesium supplementation during large-volume leukapheresis in healthy allogeneic donors. Transfusion 45:934-44
Bolan, Charles D; Yau, Yu Ying; Cullis, Herbert C et al. (2004) Pediatric large-volume leukapheresis: a single institution experience with heparin versus citrate-based anticoagulant regimens. Transfusion 44:229-38
Bolan, Charles D; Wesley, Robert A; Yau, Yu Ying et al. (2003) Randomized placebo-controlled study of oral calcium carbonate administration in plateletpheresis: I. Associations with donor symptoms. Transfusion 43:1403-13
Bolan, Charles D; Cecco, Stacey A; Yau, Yu Ying et al. (2003) Randomized placebo-controlled study of oral calcium carbonate supplementation in plateletpheresis: II. Metabolic effects. Transfusion 43:1414-22
McKee, Mark D; Cecco, Stacey A; Niemela, Julie E et al. (2002) Effects of interleukin 2 therapy on lymphocyte magnesium levels. J Lab Clin Med 139:5-12
Bolan, Charles D; Cecco, Stacey A; Wesley, Robert A et al. (2002) Controlled study of citrate effects and response to i.v. calcium administration during allogeneic peripheral blood progenitor cell donation. Transfusion 42:935-46
Bolan, C D; Greer, S E; Cecco, S A et al. (2001) Comprehensive analysis of citrate effects during plateletpheresis in normal donors. Transfusion 41:1165-71