This project focusses on the basic accuracy of NMR measurements and the design of experiments for such measurements to minimize errors due to instrumental noise. We have made experimental measurements on a number of spectrometers to verify the absence of significant correlations in the noise which would necessitate changes in the analysis. A natural extension of our earlier work on optimal design of NMR experiments is to adaptive designs, to reduce instrumental running times and improve the precision of estimates of spin lattice relaxation times. This parameter finds wide application in chemistry and medical imaging. We have developed a set of partially adaptive optimal designs which allow for two stages, in estimating T1, the design of the second being based on results from the first. This is relatively simple to implement and generally reduces the running time and increases precision. An additional extension of the theory is that of designing optimal experiments for the measurement of rate constants for in-vivo experiments. This work is still in progress.
| Dudko, Olga K; Mathe, Jerome; Szabo, Attila et al. (2007) Extracting kinetics from single-molecule force spectroscopy: nanopore unzipping of DNA hairpins. Biophys J 92:4188-95 |
| Gupta, Vaijayanti; Parisi, Michael; Sturgill, David et al. (2006) Global analysis of X-chromosome dosage compensation. J Biol 5:3 |
| Dudko, Olga K; Weiss, George H; Chernomordik, Victor (2006) Mean time-of-flight of photons in transillumination measurements of optically anisotropic tissue with an inclusion. Phys Med Biol 51:4719-33 |
| Dudko, Olga K; Weiss, George H; Chernomordik, Victor et al. (2004) Photon migration in turbid media with anisotropic optical properties. Phys Med Biol 49:3979-89 |
| Dagdug, Leonardo; Weiss, George H; Gandjbakhche, Amir H (2003) Effects of anisotropic optical properties on photon migration in structured tissues. Phys Med Biol 48:1361-70 |
| Dagdug, Leonardo; Berezhkovskii, Alexander M; Weiss, George H (2002) Number of distinct sites visited by a random walker trapped by an absorbing boundary. Phys Rev E Stat Nonlin Soft Matter Phys 66:012901 |
