The purpose of this project is to develop theory for the interpretation of biomedical and chemical measurement techniques. At present we are working on optical spectroscopy applied to estimate optical tissue parameters to distinguish between normal and abnormal tissues. The project deals with the theory of optical measurements as used to estimate optical properties of human tissue. The main subject under investigation at present is that of determining the effects of anisotropic optical parameters on measurements made in the time-gated mode, that is, when light intensities induced by a laser source irradiating tissue are measured as a function of time, rather than of the light intensity from a continuous beam measured as a function of the distance between the source and the detector. We have developed a mathematical formalism to solve problems in media whose optical parameters are anisotropic with respect to a slab geometry model, and using this model indicated how to estimate the angles that characterize the anisotropy from measurements of the light intensity as a function of time. Also under present investigation is the theory of the effects of fluorophores embedded in a tissue. Among the questions to be answered is the effects of the presence of the fluorophore on the light intensity on the surface as a function of time and as a function of spatial pattern.
| Dudko, Olga K; Mathe, Jerome; Szabo, Attila et al. (2007) Extracting kinetics from single-molecule force spectroscopy: nanopore unzipping of DNA hairpins. Biophys J 92:4188-95 |
| Gupta, Vaijayanti; Parisi, Michael; Sturgill, David et al. (2006) Global analysis of X-chromosome dosage compensation. J Biol 5:3 |
| Dudko, Olga K; Weiss, George H; Chernomordik, Victor (2006) Mean time-of-flight of photons in transillumination measurements of optically anisotropic tissue with an inclusion. Phys Med Biol 51:4719-33 |
| Dudko, Olga K; Weiss, George H; Chernomordik, Victor et al. (2004) Photon migration in turbid media with anisotropic optical properties. Phys Med Biol 49:3979-89 |
| Dagdug, Leonardo; Weiss, George H; Gandjbakhche, Amir H (2003) Effects of anisotropic optical properties on photon migration in structured tissues. Phys Med Biol 48:1361-70 |
| Dagdug, Leonardo; Berezhkovskii, Alexander M; Weiss, George H (2002) Number of distinct sites visited by a random walker trapped by an absorbing boundary. Phys Rev E Stat Nonlin Soft Matter Phys 66:012901 |
