This project involves collaborative research with NIH scientists, in which the research requires sophisticated mathematical tools or an acquaintance with theoretical methods in the physical sciences. Four major projects are current. One is with Drs. Sergei Bezrukov of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and Alexander Berezhkovskii of the National Institute of Child Health and Human Development (NICHD) on the development of models with which to interpret experimental results on the transport of ions through biological membranes. The second and third are with Dr. Attila Szabo (NIDDK). The first of these relates to the development of theoretical models for chemical reaction rates, and the second to developing the theory necessary for interpreting experimental measurements made using the technique of single-molecule spectroscopy. A fourth project is devoted to developing theory related to optical imaging techniques, together with Dr. A.H. Gandjbakhche (NIDDK). In this we have devised a model to estimate parameters that serve to characterize photon trajectories in continuous-wave measurements. - ion transport, membranes, reaction rates, spectroscopy, imaging, continuous-wave, measurements, optical

Agency
National Institute of Health (NIH)
Institute
Center for Information Technology (CIT)
Type
Intramural Research (Z01)
Project #
1Z01CT000024-23
Application #
6289563
Study Section
Special Emphasis Panel (PSL)
Project Start
Project End
Budget Start
Budget End
Support Year
23
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Center for Information Technology
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Shvartsman, Stanislav Y; Coppey, Mathieu; Berezhkovskii, Alexander M (2008) Dynamics of maternal morphogen gradients in Drosophila. Curr Opin Genet Dev 18:342-7
Vazquez, Marco-Vinicio; Berezhkovskii, Alexander M; Dagdug, Leonardo (2008) Diffusion in linear porous media with periodic entropy barriers: A tube formed by contacting spheres. J Chem Phys 129:046101
Berezhkovskii, Alexander M; Bezrukov, Sergey M (2008) Fluctuation theorem for channel-facilitated membrane transport of interacting and noninteracting solutes. J Phys Chem B 112:6228-32
Berezhkovskii, Alexander M; Weiss, George H (2008) Propagators and related descriptors for non-Markovian asymmetric random walks with and without boundaries. J Chem Phys 128:044914
Berezhkovskii, Alexander M; Bezrukov, Sergey M (2008) Counting translocations of strongly repelling particles through single channels: fluctuation theorem for membrane transport. Phys Rev Lett 100:038104
Coppey, Mathieu; Boettiger, Alistair N; Berezhkovskii, Alexander M et al. (2008) Nuclear trapping shapes the terminal gradient in the Drosophila embryo. Curr Biol 18:915-9
Bezrukov, Sergey M; Berezhkovskii, Alexander M; Szabo, Attila (2007) Diffusion model of solute dynamics in a membrane channel: mapping onto the two-site model and optimizing the flux. J Chem Phys 127:115101
Dagdug, Leonardo; Berezhkovskii, Alexander M; Makhnovskii, Yurii A et al. (2007) Transient diffusion in a tube with dead ends. J Chem Phys 127:224712
Berezhkovskii, A M; Pustovoit, M A; Bezrukov, S M (2007) Diffusion in a tube of varying cross section: numerical study of reduction to effective one-dimensional description. J Chem Phys 126:134706
Berezhkovskii, A M; Barzykin, A V (2007) Simple formulas for the trapping rate by nonspherical absorber and capacitance of nonspherical conductor. J Chem Phys 126:106102

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