Abstract

These studies are directed at a better understanding of the behavioral effects of drugs acting on dopamine neurotransmission. Several previous studies had results indicating that selective D1 or D2 dopamine agonists and antagonists were not functioning as they would be expected based on their in vitro pharmacology. Subsequent studies have been directed at quantitative assessments of behavioral effects of agonist-antagonist interactions. These studies have utilized several different behavioral endpoints, including grossly observable behavior, locomotor activity, consummatory behavior, learned operant behavior, and drug discrimination. In addition, a series of studies is examining the behavioral effects of drugs that are thought to bind irreversibly to the dopamine transporter. These studies will provide answers to several basic questions regarding the functioning of this site as well as provide information that may be of use in the development of drugs to treat cocaine abuse. Finally, studies are being conducted that address the interactions of the dopamine system with cholinergic and GABAergic systems.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Intramural Research (Z01)
Project #
1Z01DA000105-01
Application #
3853705
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Tanda, Gianluigi; Katz, Jonathan L (2007) Muscarinic preferential M(1) receptor antagonists enhance the discriminative-stimulus effects of cocaine in rats. Pharmacol Biochem Behav 87:400-4
Katz, Jonathan L; Kopajtic, Theresa A; Terry, Philip (2006) Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats. Behav Pharmacol 17:303-9
Desai, Rajeev I; Terry, Philip; Katz, Jonathan L (2005) A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice. Pharmacol Biochem Behav 81:843-8
Katz, Jonathan L; Higgins, Stephen T (2003) The validity of the reinstatement model of craving and relapse to drug use. Psychopharmacology (Berl) 168:21-30
McMillan, Donald E; Katz, Jonathan L (2002) Continuing implications of the early evidence against the drive-reduction hypothesis of the behavioral effects of drugs. Psychopharmacology (Berl) 163:251-64
Chausmer, Allison L; Elmer, Gregory I; Rubinstein, Marcelo et al. (2002) Cocaine-induced locomotor activity and cocaine discrimination in dopamine D2 receptor mutant mice. Psychopharmacology (Berl) 163:54-61
Chausmer, Allison L; Katz, Jonathan L (2002) Comparison of interactions of D1-like agonists, SKF 81297, SKF 82958 and A-77636, with cocaine: locomotor activity and drug discrimination studies in rodents. Psychopharmacology (Berl) 159:145-53
Mead, Andy N; Rocha, Beatriz A; Donovan, David M et al. (2002) Intravenous cocaine induced-activity and behavioural sensitization in norepinephrine-, but not dopamine-transporter knockout mice. Eur J Neurosci 16:514-20
Mead, Andy N; Katz, Jonathan L; Rocha, Beatriz A (2002) Intravenous cocaine-induced activity in A/J and C57BL/6J mice: behavioral sensitization and conditioned activity. Neuropharmacology 42:976-86
Bergman, Jack; Katz, Jonathan L; Miczek, Klaus A (2002) The experimental imperative. Psychopharmacology (Berl) 163:249-50

Showing the most recent 10 out of 14 publications