Abstract

The CNS synthesizes and secretes several neuropeptides which attenuate the actions of morphine including CCK-8, Tyr-MIF, Phe-Leu-Phe-Gln-Pro- Gln-Arg-Phe-NH2 (NPFF), alpha-MSH and dynorphin(1-17). The anti-opioid model of tolerance and dependence poere obtained. Analyses

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Intramural Research (Z01)
Project #
1Z01DA000120-02
Application #
3775020
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Wang, Xiaoying; Xu, Heng; Rothman, Richard B (2006) Regulation of the rat brain endothelin system by endogenous beta-endorphin. Peptides 27:769-74
Wang, X; Xu, H; Rothman, R B (2004) Intracerebroventricular administration of anti-endothelin-1 IgG selectively upregulates endothelin-A and kappa opioid receptors. Neuroscience 129:751-6
Rothman, Richard B; Vu, Nga; Wang, Xiaoying et al. (2003) Endogenous CART peptide regulates mu opioid and serotonin 5-HT(2A) receptors. Peptides 24:413-7
Rothman, Richard B; Vu, Nga; Xu, Heng et al. (2002) Endogenous corticotropin releasing factor regulates adrenergic and opioid receptors. Peptides 23:2177-80