Histamine release from mast cells and blood basophils is being studied as one of the immunological mechanisms involved in inflamation. It is also a model for cell secretion. Among the histamine releasing agents employed are IgE antibody, other secretagogues, LHRH peptides, and the calcium ionophore A23187. Cultured rat b asophilic leukemia cells are used as a model for the studies of the IgE receptor and of biochemical changes during cell activation. Large numbers of cells can be obtained for biochemical studies and biochemical variants have been selected which are defective at different sites in the pathway of cell activation and secretion.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Intramural Research (Z01)
Project #
1Z01DE000034-25
Application #
3775528
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
25
Fiscal Year
1993
Total Cost
Indirect Cost
Name
National Institute of Dental & Craniofacial Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code