Abstract

The purpose of this project is to elucidate the neural mechanisms and principles of treatment of chronic pain syndromes. We are conducting clinical trials of single drugs, drug combinations, and alternative medicine techniques in chronic lumbar radiculopathy pain. A new program in pain genetics has localized a gene affecting pain behaviors to a small region of one chromosome containing several genes whose gene products have previously been linked to pain processing. Candidate gene studies are beginning in a cohort of 500 patients with 10-year followup of sciatica in the Maine Lumbar Spine Study, and with cohorts of patients with other neuropathic pain disorders and temporomandibular disorder.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Intramural Research (Z01)
Project #
1Z01DE000366-21
Application #
6814427
Study Section
(PNMB)
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
Dental & Craniofacial Research
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Slade, Gary D; Diatchenko, Luda; Ohrbach, Richard et al. (2008) Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder. Semin Orthod 14:146-156
Lotsch, Jorn; Belfer, Inna; Kirchhof, Anja et al. (2007) Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms. Clin Chem 53:1010-5
Khoromi, Suzan; Blackman, Marc R; Kingman, Albert et al. (2007) Low intensity permanent magnets in the treatment of chronic lumbar radicular pain. J Pain Symptom Manage 34:434-45
Belfer, I; Hipp, H; Bollettino, A et al. (2007) Alcoholism is associated with GALR3 but not two other galanin receptor genes. Genes Brain Behav 6:473-81
Khoromi, Suzan; Cui, Lihong; Nackers, Lisa et al. (2007) Morphine, nortriptyline and their combination vs. placebo in patients with chronic lumbar root pain. Pain 130:66-75
Edwards, Robert R; Klick, Brendan; Buenaver, Luis et al. (2007) Symptoms of distress as prospective predictors of pain-related sciatica treatment outcomes. Pain 130:47-55
Max, Mitchell B; Wu, Tianxia; Atlas, Steven J et al. (2006) A clinical genetic method to identify mechanisms by which pain causes depression and anxiety. Mol Pain 2:14
Tegeder, Irmgard; Costigan, Michael; Griffin, Robert S et al. (2006) GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 12:1269-77
Khoromi, Suzan; Muniyappa, Ranganath; Nackers, Lisa et al. (2006) Effects of chronic osteoarthritis pain on neuroendocrine function in men. J Clin Endocrinol Metab 91:4313-8
Edwards, Robert R; Haythornthwaite, Jennifer A; Tella, Prabhav et al. (2006) Basal heat pain thresholds predict opioid analgesia in patients with postherpetic neuralgia. Anesthesiology 104:1243-8

Showing the most recent 10 out of 43 publications