Identification and Characterization of Receptors for Gi Peptides

Jensen, R T.

Abstract

These studies involve the identification of receptors for gastrointestinal peptides by developing selective radioligands for specific receptors, specific potent antagonists, and the characterization of receptors using these ligands, antagonists, cross-linking studies, solubilization and eventually structural determination.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Intramural Research (Z01)
• Project #: 1Z01DK053100-03
• Application #: 3855402
• Support Year: 3
• Fiscal Year: 1991

Institution

• Name: National Institute of Diabetes and Digestive and Kidney Diseases
• Country: United States

Publications

Nuche-Berenguer, Bernardo; Jensen, R T (2015) Gastrointestinal hormones/neurotransmitters and growth factors can activate P21 activated kinase 2 in pancreatic acinar cells by novel mechanisms. Biochim Biophys Acta 1853:2371-82

Alves, Bryce N; Marshall, Kristen; Tamang, David L et al. (2009) Lipid-dependent cytotoxicity by the lipase PLRP2 and by PLRP2-positive cytotoxic T lymphocytes (CTLs). Cell Biochem Funct 27:296-308

Berna, Marc J; Tapia, Jose A; Sancho, Veronica et al. (2009) Gastrointestinal growth factors and hormones have divergent effects on Akt activation. Cell Signal 21:622-38

Alves, Bryce N; Leong, Jeff; Tamang, David L et al. (2009) Pancreatic lipase-related protein 2 (PLRP2) induction by IL-4 in cytotoxic T lymphocytes (CTLs) and reevaluation of the negative effects of its gene ablation on cytotoxicity. J Leukoc Biol 86:701-12

Gonzalez, Nieves; Nakagawa, Tomoo; Mantey, Samuel A et al. (2009) Molecular basis for the selectivity of the mammalian bombesin peptide, neuromedin B, for its receptor. J Pharmacol Exp Ther 331:265-76

Moody, Terry W; Pradhan, Tapas; Mantey, Samuel A et al. (2008) Bombesin marine toxin conjugates inhibit the growth of lung cancer cells. Life Sci 82:855-61

Schumann, Michael; Nakagawa, Tomoo; Mantey, Samuel A et al. (2008) Function of non-visual arrestins in signaling and endocytosis of the gastrin-releasing peptide receptor (GRP receptor). Biochem Pharmacol 75:1170-85

Jensen, R T; Battey, J F; Spindel, E R et al. (2008) International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev 60:1-42

Seidita, G; Mirisola, M; D'Anna, R P et al. (2008) Analysis of the gastrin-releasing peptide receptor gene in Italian patients with autism spectrum disorders. Am J Med Genet B Neuropsychiatr Genet 147B:807-13

Igarashi, Hisato; Ito, Tetsuhide; Kuwano-Kojima, Mizuho et al. (2008) Involvement of VPAC1 and VPAC2 receptors in increasing local pancreatic blood flow in anesthetized rats. Pancreas 37:236-8