Management of Islet Cell Tumors

Maton, P N.

Abstract

Studies involving patients with islet cell tumors (Zollinger Ellison syndrome, insulinoma, VIPoma) are directed to further understanding the pathogenesis of the syndromes and to developing alternative, more effective modes of therapy utilizing both medical and surgical approaches.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Intramural Research (Z01)
• Project #: 1Z01DK053200-01
• Application #: 3876435
• Support Year: 1
• Fiscal Year: 1990

Institution

• Name: National Institute of Diabetes and Digestive and Kidney Diseases
• Country: United States

Publications

Metz, David C; Cadiot, Guillaume; Poitras, Pierre et al. (2017) Diagnosis of Zollinger-Ellison syndrome in the era of PPIs, faulty gastrin assays, sensitive imaging and limited access to acid secretory testing. Int J Endocr Oncol 4:167-185

Ito, Tetsuhide; Igarashi, Hisato; Uehara, Hirotsugu et al. (2013) Causes of death and prognostic factors in multiple endocrine neoplasia type 1: a prospective study: comparison of 106 MEN1/Zollinger-Ellison syndrome patients with 1613 literature MEN1 patients with or without pancreatic endocrine tumors. Medicine (Baltimore) 92:135-81

Metz, David C; Jensen, Robert T (2008) Gastrointestinal Neuroendocrine Tumors: Pancreatic Endocrine Tumors. Gastroenterology :

Norton, Jeffrey A; Venzon, David J; Berna, Marc J et al. (2008) Prospective study of surgery for primary hyperparathyroidism (HPT) in multiple endocrine neoplasia-type 1 and Zollinger-Ellison syndrome: long-term outcome of a more virulent form of HPT. Ann Surg 247:501-10

Long, Scott H; Berna, Marc J; Thill, Michelle et al. (2007) Secretin-receptor and secretin-receptor-variant expression in gastrinomas: correlation with clinical and tumoral features and secretin and calcium provocative test results. J Clin Endocrinol Metab 92:4394-402

Norton, Jeffrey A; Jensen, Robert T (2007) Role of surgery in Zollinger-Ellison syndrome. J Am Coll Surg 205:S34-7

Hoffmann, K Martin; Gibril, Fathia; Entsuah, Laurence K et al. (2006) Patients with multiple endocrine neoplasia type 1 with gastrinomas have an increased risk of severe esophageal disease including stricture and the premalignant condition, Barrett's esophagus. J Clin Endocrinol Metab 91:204-12

Jensen, Robert T (2006) Consequences of long-term proton pump blockade: insights from studies of patients with gastrinomas. Basic Clin Pharmacol Toxicol 98:4-19

Norton, Jeffrey A; Fraker, Douglas L; Alexander, H R et al. (2006) Surgery increases survival in patients with gastrinoma. Ann Surg 244:410-9

Jensen, Robert T; Rindi, Guido; Arnold, Rudolf et al. (2006) Well-differentiated duodenal tumor/carcinoma (excluding gastrinomas). Neuroendocrinology 84:165-72