Epidemiology of Complications of Non-Insulin Dependent Diabetes

Knowler, William C.

Abstract

The purpose of this project is to determine the incidence rates, rates of progression, and risk factors for the chronic complications of type 2 diabetes. The study is conducted in the Pima Indians of the Gila River Indian Community, who have participated in a longitudinal epidemiologic study since 1965 (see project Z01 DK 69000). Risk factors for the major complications of diabetes, retinopathy, nephropathy, and coronary artery disease, are determined by longitudinal follow-up of diabetic subjects. Methods of ascertainment of these complications include fundus photography, measurement of urine albumin and serum creatinine concentrations, and electrocardiography. Results of a segregation analysis suggest a major effect of a single gene on risk of nephropathy as a function of duration of diabetes. The group is taking part in a multicentered genetic linkage study (Family Investigation of Nephropathy and Diabetes) of diabetic nephropathy in an attempt to identify such a susceptibility gene.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Intramural Research (Z01)
• Project #: 1Z01DK069036-11
• Application #: 6432204
• Study Section: (PECR)
• Support Year: 11
• Fiscal Year: 2000

Institution

• Name: U.S. National Inst Diabetes/Digst/Kidney
• Country: United States

Publications

Pavkov, Meda E; Weil, E Jennifer; Fufaa, Gudeta D et al. (2016) Tumor necrosis factor receptors 1 and 2 are associated with early glomerular lesions in type 2 diabetes. Kidney Int 89:226-34

Foster, Meredith C; Inker, Lesley A; Hsu, Chi-Yuan et al. (2015) Filtration markers as predictors of ESRD and mortality in Southwestern American Indians with type 2 diabetes. Am J Kidney Dis 66:75-83

Nelson, Robert G; Pavkov, Meda E; Hanson, Robert L et al. (2008) Changing course of diabetic nephropathy in the Pima Indians. Diabetes Res Clin Pract 82 Suppl 1:S10-4

Nelson, Robert G (2008) Kidney disease in childhood-onset diabetes. Am J Kidney Dis 52:407-11

Pavkov, Meda E; Hanson, Robert L; Knowler, William C et al. (2007) Changing patterns of type 2 diabetes incidence among Pima Indians. Diabetes Care 30:1758-63

Look AHEAD Research Group; Pi-Sunyer, Xavier; Blackburn, George et al. (2007) Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care 30:1374-83

Looker, Helen C; Fagot-Campagna, Anne; Gunter, Elaine W et al. (2007) Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res Rev 23:193-201

Xu, Jiaqiong; Knowler, William C; Devereux, Richard B et al. (2007) Albuminuria within the ""normal"" range and risk of cardiovascular disease and death in American Indians: the Strong Heart Study. Am J Kidney Dis 49:208-16

Shultis, Wendy A; Weil, E Jennifer; Looker, Helen C et al. (2007) Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care 30:306-11

Pavkov, M E; Knowler, W C; Bennett, P H et al. (2006) Increasing incidence of proteinuria and declining incidence of end-stage renal disease in diabetic Pima Indians. Kidney Int 70:1840-6