Abstract

The purpose of this project is to determine the incidence rates, rates of progression, and risk factors for the chronic complications of type 2 diabetes. The study is conducted in the Pima Indians of the Gila River Indian Community, who have participated in a longitudinal epidemiologic study since 1965 (see project Z01 DK 69000). Risk factors for the major complications of diabetes, retinopathy, nephropathy, and coronary artery disease, are determined by longitudinal follow-up of diabetic subjects. Methods of ascertainment of these complications include fundus photography, measurement of urine albumin and serum creatinine concentrations, and electrocardiography. The incidence of diabetic nephropathy, as a function of duration of diabetes, was unrelated to age of onset of diabetes. Thus, risk of this complication is much more strongly related to characteristics of diabetes rather than age per se. The group is taking part in a multicentered genetic linkage study (Family Investigation of Nephropathy and Diabetes) of diabetic nephropathy in an attempt to identify susceptibility genes for nephropathy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Intramural Research (Z01)
Project #
1Z01DK069036-12
Application #
6532209
Study Section
(PECR)
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Pavkov, Meda E; Weil, E Jennifer; Fufaa, Gudeta D et al. (2016) Tumor necrosis factor receptors 1 and 2 are associated with early glomerular lesions in type 2 diabetes. Kidney Int 89:226-34
Foster, Meredith C; Inker, Lesley A; Hsu, Chi-Yuan et al. (2015) Filtration markers as predictors of ESRD and mortality in Southwestern American Indians with type 2 diabetes. Am J Kidney Dis 66:75-83
Nelson, Robert G; Pavkov, Meda E; Hanson, Robert L et al. (2008) Changing course of diabetic nephropathy in the Pima Indians. Diabetes Res Clin Pract 82 Suppl 1:S10-4
Nelson, Robert G (2008) Kidney disease in childhood-onset diabetes. Am J Kidney Dis 52:407-11
Pavkov, Meda E; Hanson, Robert L; Knowler, William C et al. (2007) Changing patterns of type 2 diabetes incidence among Pima Indians. Diabetes Care 30:1758-63
Look AHEAD Research Group; Pi-Sunyer, Xavier; Blackburn, George et al. (2007) Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care 30:1374-83
Looker, Helen C; Fagot-Campagna, Anne; Gunter, Elaine W et al. (2007) Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res Rev 23:193-201
Xu, Jiaqiong; Knowler, William C; Devereux, Richard B et al. (2007) Albuminuria within the ""normal"" range and risk of cardiovascular disease and death in American Indians: the Strong Heart Study. Am J Kidney Dis 49:208-16
Shultis, Wendy A; Weil, E Jennifer; Looker, Helen C et al. (2007) Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes. Diabetes Care 30:306-11
Pavkov, M E; Knowler, W C; Bennett, P H et al. (2006) Increasing incidence of proteinuria and declining incidence of end-stage renal disease in diabetic Pima Indians. Kidney Int 70:1840-6

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